Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5198
Title: Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder
Authors: Yorukoglu, K.
Tuna, B.
Dikicioglu, E.
Düzcan, Ender
Isisag, A.
Sen, S.
Mungan, U.
Keywords: Bladder neoplasms
Classification
Urothelium
World Health Organization
bladder cancer
cancer classification
cancer grading
clinical article
diagnostic accuracy
evaluation
health care organization
histopathology
human
human tissue
nomenclature
observer variation
papillary carcinoma
practice guideline
priority journal
reproducibility
review
standard
statistical analysis
technique
tissue section
urogenital tract cancer
world health organization
Carcinoma, Papillary
Humans
Reproducibility of Results
Urinary Bladder Neoplasms
Abstract: Objectives: This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification. Methods: A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic). Results: A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications. Conclusions: The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.
URI: https://hdl.handle.net/11499/5198
https://doi.org/10.1007/s00428-003-0905-0
ISSN: 0945-6317
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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