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https://hdl.handle.net/11499/5198
Title: | Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder | Authors: | Yorukoglu, K. Tuna, B. Dikicioglu, E. Düzcan, Ender Isisag, A. Sen, S. Mungan, U. |
Keywords: | Bladder neoplasms Classification Urothelium World Health Organization bladder cancer cancer classification cancer grading clinical article diagnostic accuracy evaluation health care organization histopathology human human tissue nomenclature observer variation papillary carcinoma practice guideline priority journal reproducibility review standard statistical analysis technique tissue section urogenital tract cancer world health organization Carcinoma, Papillary Humans Reproducibility of Results Urinary Bladder Neoplasms |
Abstract: | Objectives: This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification. Methods: A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic). Results: A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications. Conclusions: The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management. | URI: | https://hdl.handle.net/11499/5198 https://doi.org/10.1007/s00428-003-0905-0 |
ISSN: | 0945-6317 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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