Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52053
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dc.contributor.authorAltıncık, Selda Ayca-
dc.contributor.authorYıldırımçakar, Didem-
dc.contributor.authorAvcı, Esin-
dc.contributor.authorÖzhan, Bayram-
dc.contributor.authorGirişgen, İlknur-
dc.contributor.authorYüksel, Selçuk-
dc.date.accessioned2023-08-22T18:49:10Z-
dc.date.available2023-08-22T18:49:10Z-
dc.date.issued2023-
dc.identifier.issn0931-041X-
dc.identifier.issn1432-198X-
dc.identifier.urihttps://hdl.handle.net/11499/52053-
dc.identifier.urihttps://doi.org/10.1007/s00467-023-06019-4-
dc.description.abstractBackground Glomerular endothelial dysfunction and neoangiogenesis play a significant role in the pathogenesis of diabetic kidney disease (DKD). Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a recently discovered protein that participates in the molecular pathway of inflammation and angiogenesis. We aimed to investigate efficacy of LRG1 to predict estimated glomerular filtration rate (eGFR) decrease in children and adolescents with type 1 diabetes mellitus (T1DM). Methods The study comprised 72 participants with diabetes duration for >= 2 years. At study initiation, LRG1, urine albumin, eGFR (cystatin C-based, and Schwartz), HbA1c, and lipid values were evaluated and diabetes-related clinical features and anthropometric measurements were collected. These results were compared with final control values after >= 1 year. Patients were divided into subgroups according to presence of albuminuria progression, eGFR decrease, and metabolic control parameters. Results There was positive correlation between LRG1 level and Schwartz and cystatin C-based eGFR decline (r = 0.360, p = 0.003; r = 0.447, p = 0.001, respectively), and negative correlation between final cystatin C-based eGFR and LRG1 (p = 0.01, r = -0.345). Patients with cystatin C-based eGFR decrease > 10% had significantly higher LRG1 levels (p = 0.03), however, LRG1 was not different between albuminuria progression subgroups. A 0.282 mu g/ml increase in LRG1 correlated with a 1% decrease in eGFR in simple linear regression analysis (beta = 0.282, %CI 0.11-0.45, p = 0.001) and LRG1 was an independent predictor of GFR decline even in the presence of covariates. Conclusions Our study supports the relationship between plasma LRG1 and eGFR decline and suggests LRG1 may be an early marker of DKD progression in children with T1DM.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Nephrologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectDiabetic kidney diseaseen_US
dc.subjectLeucine-rich alpha-2-glycoprotein 1en_US
dc.subjectType 1 diabetes mellitusen_US
dc.subjectLrg1 Promotes Angiogenesisen_US
dc.subjectHyperfiltrationen_US
dc.subjectProgressionen_US
dc.subjectMigrationen_US
dc.subjectAdultsen_US
dc.titlePlasma leucine-rich alpha-2-glycoprotein 1-a novel marker of diabetic kidney disease in children and adolescents with type 1 diabetes mellitus?en_US
dc.typeArticleen_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1007/s00467-023-06019-4-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57195296126-
dc.authorscopusid57221387745-
dc.authorscopusid57209468091-
dc.authorscopusid23469982500-
dc.authorscopusid36657292800-
dc.authorscopusid8514659100-
dc.identifier.pmid37401956en_US
dc.identifier.scopus2-s2.0-85163817947en_US
dc.identifier.wosWOS:001025090000001en_US
dc.institutionauthor-
dc.identifier.scopusqualityQ1-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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