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https://hdl.handle.net/11499/52087
Title: | The effect of heart failure on gut microbial richness and diversity | Authors: | Kılıç, Oğuz Kaya, Halil İbrahim Seçme, Mucahit Kılınç, Mehmet Sevgican, Cihan İlyas Büber, İpek Dodurga, Yavuz Şimşek, Ömer Ergin, Çağrı Kılıç, İsmail Doğu |
Keywords: | Heart failure Coronary artery disease Microbiota Intestinal Diversity Trimethylamine-N-Oxide Cardiovascular Health |
Publisher: | Elsevier Espana Slu | Abstract: | Introduction and objective: With recent advances in genome sequencing technology, a large body of evidence has accumulated over the last few years linking alterations in microbiota with cardiovascular disease. In this study, we aimed to compare gut microbial composition using 16S ribosomal DNA (rDNA) sequencing techniques in patients with coronary artery disease (CAD) and stable heart failure (HF) with reduced ejection fraction and patients with CAD but with normal ejection fraction. We also studied the relationship between systemic inflammatory markers and microbial richness and diversity.Methods: A total of 40 patients (19 with HF and CAD, 21 with CAD but without HF) were included in the study. HF was defined as left ventricular ejection fraction <40%. Only stable ambulatory patients were included in the study. Gut microbiota were assessed from the participants' fecal samples. The diversity and richness of microbial populations in each sample were assessed by the Chao1-estimated OTU number and the Shannon index.Results: The Chao1-estimated OTU number and Shannon index were similar between HF and control groups. There was no statistically significant relationship between inflammatory marker levels (tumor necrosis factor-alpha, interleukin 1-beta, endotoxin, C-reactive protein, galectin-3, interleukin 6, and lipopolysaccharide-binding protein) and microbial richness and diversity when analyzed at the phylum level. | URI: | https://hdl.handle.net/11499/52087 https://doi.org/10.1016/j.repc.2022.06.016 |
ISSN: | 0870-2551 0304-4750 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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1-s2.0-S0870255123001208-main.pdf | 1.65 MB | Adobe PDF | View/Open |
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