Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52087
Title: The effect of heart failure on gut microbial richness and diversity
Authors: Kılıç, Oğuz
Kaya, Halil İbrahim
Seçme, Mucahit
Kılınç, Mehmet
Sevgican, Cihan İlyas
Büber, İpek
Dodurga, Yavuz
Şimşek, Ömer
Ergin, Çağrı
Kılıç, İsmail Doğu
Keywords: Heart failure
Coronary artery disease
Microbiota
Intestinal
Diversity
Trimethylamine-N-Oxide
Cardiovascular Health
Publisher: Elsevier Espana Slu
Abstract: Introduction and objective: With recent advances in genome sequencing technology, a large body of evidence has accumulated over the last few years linking alterations in microbiota with cardiovascular disease. In this study, we aimed to compare gut microbial composition using 16S ribosomal DNA (rDNA) sequencing techniques in patients with coronary artery disease (CAD) and stable heart failure (HF) with reduced ejection fraction and patients with CAD but with normal ejection fraction. We also studied the relationship between systemic inflammatory markers and microbial richness and diversity.Methods: A total of 40 patients (19 with HF and CAD, 21 with CAD but without HF) were included in the study. HF was defined as left ventricular ejection fraction <40%. Only stable ambulatory patients were included in the study. Gut microbiota were assessed from the participants' fecal samples. The diversity and richness of microbial populations in each sample were assessed by the Chao1-estimated OTU number and the Shannon index.Results: The Chao1-estimated OTU number and Shannon index were similar between HF and control groups. There was no statistically significant relationship between inflammatory marker levels (tumor necrosis factor-alpha, interleukin 1-beta, endotoxin, C-reactive protein, galectin-3, interleukin 6, and lipopolysaccharide-binding protein) and microbial richness and diversity when analyzed at the phylum level.
URI: https://hdl.handle.net/11499/52087
https://doi.org/10.1016/j.repc.2022.06.016
ISSN: 0870-2551
0304-4750
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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