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https://hdl.handle.net/11499/5212
Title: | Inhibition of spinal reflexes by acetylsalicylate and metamizol (dipyrone) in rats | Authors: | Genç, Osman Turgut, Sebahat Turgut, Günfer Kortunay, Selim |
Keywords: | Acetylsalicylate Metamizol (dipyrone) Spinal reflexes Spinalized rat acetylsalicylic acid calcium anesthetic agent dipyrone ketamine prostaglandin synthase inhibitor anesthesia animal experiment article artificial ventilation back controlled study electrostimulation inhibition kinetics laminectomy monosynaptic reflex nerve stimulation nonhuman priority journal rat sciatic nerve spinal reflex statistical significance Animals Anti-Inflammatory Agents, Non-Steroidal Aspirin Decerebrate State Dipyrone Lumbosacral Region Rats Rats, Wistar Reflex, Monosynaptic Spinal Cord |
Abstract: | The effects of acetylsalicylate and metamizol on spinal monosynaptic reflexes were tested in spinal rats. Adult rats were anesthetized with ketamine, artificially ventilated, and spinalized at the C1 level. A laminectomy was performed in the lumbosacral region. Following electrical stimulation of the sciatic nerve by single pulses, the reflex potentials were recorded from the ipsilateral L5 ventral root. Acetylsalicylate was administered orally via nasogastric tube and metamizol intramuscularly. Acetylsalicylate (50 and 100 mg/kg) and metamizol (15 mg/kg) significantly decreased the amplitude of the reflex response (p < 0.05). But the 10-mg/kg metamizol dose did not significantly decrease the amplitude of the reflex response. The cyclooxygenase products of arachidonic acid may play an important role in regulating the reflex potential. Copyright © 2003 S. Karger AG, Basel. | URI: | https://hdl.handle.net/11499/5212 https://doi.org/10.1159/000072663 |
ISSN: | 0031-7012 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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