Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5212
Title: Inhibition of spinal reflexes by acetylsalicylate and metamizol (dipyrone) in rats
Authors: Genç, Osman
Turgut, Sebahat
Turgut, Günfer
Kortunay, Selim
Keywords: Acetylsalicylate
Metamizol (dipyrone)
Spinal reflexes
Spinalized rat
acetylsalicylic acid calcium
anesthetic agent
dipyrone
ketamine
prostaglandin synthase inhibitor
anesthesia
animal experiment
article
artificial ventilation
back
controlled study
electrostimulation
inhibition kinetics
laminectomy
monosynaptic reflex
nerve stimulation
nonhuman
priority journal
rat
sciatic nerve
spinal reflex
statistical significance
Animals
Anti-Inflammatory Agents, Non-Steroidal
Aspirin
Decerebrate State
Dipyrone
Lumbosacral Region
Rats
Rats, Wistar
Reflex, Monosynaptic
Spinal Cord
Abstract: The effects of acetylsalicylate and metamizol on spinal monosynaptic reflexes were tested in spinal rats. Adult rats were anesthetized with ketamine, artificially ventilated, and spinalized at the C1 level. A laminectomy was performed in the lumbosacral region. Following electrical stimulation of the sciatic nerve by single pulses, the reflex potentials were recorded from the ipsilateral L5 ventral root. Acetylsalicylate was administered orally via nasogastric tube and metamizol intramuscularly. Acetylsalicylate (50 and 100 mg/kg) and metamizol (15 mg/kg) significantly decreased the amplitude of the reflex response (p < 0.05). But the 10-mg/kg metamizol dose did not significantly decrease the amplitude of the reflex response. The cyclooxygenase products of arachidonic acid may play an important role in regulating the reflex potential. Copyright © 2003 S. Karger AG, Basel.
URI: https://hdl.handle.net/11499/5212
https://doi.org/10.1159/000072663
ISSN: 0031-7012
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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