Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52124
Title: Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study
Authors: Aksu, Bağdagül
Afonso, Alberto Caldas
Akil, İpek
Alpay, Harika
Atmış, Bahriye
Aydoğ, Özlem
Karabay Bayazıt, Aysun
Bayram, Meral Torun
Bilge, Ilmay
Buyukkaragoz, Bahar
Comak, Elif
Demir, Belde Kasap
Dincel, Nida
Donmez, Osman
Durmus, Mehmet Akif
Dursun, Hasan
Dusunsel, Ruhan
Duzova, Ali
Ertan, Pelin
Gedikbasi, Asuman
Goknar, Nilufer
Guven, Sercin
Hacihamdioglu, Duygu
Jankauskiene, Augustina
Kalyoncu, Mukaddes
Kavukcu, Salih
Kenan, Bahriye Uzun
Kucuk, Nuran
Kural, Bahar
Litwin, Mieczyslaw
Montini, Giovanni
Morello, William
Obrycki, Lukasz
Omer, Beyhan
Oner, Huseyin
Ozdemir, Ebru Misirli
Ozkayin, Nese
Paripovic, Dusan
Pehlivanoglu, Cemile
Saygili, Seha
Schaefer, Susanne
Sonmez, Ferah
Tabel, Yilmaz
Tas, Nesrin
Tasdemir, Mehmet
Teixeira, Ana
Tekcan, Demet
Topaloglu, Rezan
Tulpar, Sebahat
Turkkan, Ozde Nisa
Uysal, Berfin
Uysalol, Metin
Vitkevic, Renata
Yavuz, Sevgi
Yel, Sibel
Yildirim, Tarik
Yildirim, Zeynep Yuruk
Yildiz, Nurdan
Yüksel, Selçuk
Yurtseven, Eray
Yilmaz, Alev
Keywords: Toll-like receptor 4
TLR4
Urinary tract infection
UTI
UTILISE study
Interleukin-8
Expression
Uti
Publisher: Springer
Abstract: Background One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study.Methods A total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI.Results Urine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001).Conclusions Urine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI.
Description: Article; Early Access
URI: https://hdl.handle.net/11499/52124
https://doi.org/10.1007/s00467-023-06063-0
ISSN: 0931-041X
1432-198X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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