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https://hdl.handle.net/11499/52124
Title: | Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study | Authors: | Aksu, Bağdagül Afonso, Alberto Caldas Akil, İpek Alpay, Harika Atmış, Bahriye Aydoğ, Özlem Karabay Bayazıt, Aysun Bayram, Meral Torun Bilge, Ilmay Buyukkaragoz, Bahar Comak, Elif Demir, Belde Kasap Dincel, Nida Donmez, Osman Durmus, Mehmet Akif Dursun, Hasan Dusunsel, Ruhan Duzova, Ali Ertan, Pelin Gedikbasi, Asuman Goknar, Nilufer Guven, Sercin Hacihamdioglu, Duygu Jankauskiene, Augustina Kalyoncu, Mukaddes Kavukcu, Salih Kenan, Bahriye Uzun Kucuk, Nuran Kural, Bahar Litwin, Mieczyslaw Montini, Giovanni Morello, William Obrycki, Lukasz Omer, Beyhan Oner, Huseyin Ozdemir, Ebru Misirli Ozkayin, Nese Paripovic, Dusan Pehlivanoglu, Cemile Saygili, Seha Schaefer, Susanne Sonmez, Ferah Tabel, Yilmaz Tas, Nesrin Tasdemir, Mehmet Teixeira, Ana Tekcan, Demet Topaloglu, Rezan Tulpar, Sebahat Turkkan, Ozde Nisa Uysal, Berfin Uysalol, Metin Vitkevic, Renata Yavuz, Sevgi Yel, Sibel Yildirim, Tarik Yildirim, Zeynep Yuruk Yildiz, Nurdan Yüksel, Selçuk Yurtseven, Eray Yilmaz, Alev |
Keywords: | Toll-like receptor 4 TLR4 Urinary tract infection UTI UTILISE study Interleukin-8 Expression Uti |
Publisher: | Springer | Abstract: | Background One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim was to determine whether soluble TLR4 (sTLR4), soluble TLR5 (sTLR5) and interleukin 8 (IL-8) can be used as biomarkers to diagnose UTI. We also aimed to reveal the relationship between urine Heat Shock Protein 70 (uHSP70) and those biomarkers investigated in this study.Methods A total of 802 children from 37 centers participated in the study. The participants (n = 282) who did not meet the inclusion criteria were excluded from the study. The remaining 520 children, including 191 patients with UTI, 178 patients with non-UTI infections, 50 children with contaminated urine samples, 26 participants with asymptomatic bacteriuria and 75 healthy controls were included in the study. Urine and serum levels of sTLR4, sTLR5 and IL-8 were measured at presentation in all patients and after antibiotic treatment in patients with UTI.Results Urine sTLR4 was higher in the UTI group than in the other groups. UTI may be predicted using 1.28 ng/mL as cut-off for urine sTLR4 with 68% sensitivity and 65% specificity (AUC = 0.682). In the UTI group, urine sTLR4 levels were significantly higher in pyelonephritis than in cystitis (p < 0.0001). Post-treatment urine sTLR4 levels in the UTI group were significantly lower than pre-treatment values (p < 0.0001).Conclusions Urine sTLR4 may be used as a useful biomarker in predicting UTI and subsequent pyelonephritis in children with UTI. | Description: | Article; Early Access | URI: | https://hdl.handle.net/11499/52124 https://doi.org/10.1007/s00467-023-06063-0 |
ISSN: | 0931-041X 1432-198X |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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