Vitamin D Efficacy on Prognosis of Bladder Cancer Patients

Abstract

Objectives: This study aimed to investigate the predictive value of vitamin D levels in patients with bladder cancer before systemic treatment. Methods: A total of 125 bladder cancer patients were included in the study. The Kaplan–Meier method was used to estimate overall survival (OS) and progression-free survival (PFS), and the long-rank test was used for comparison. Uni- variate and multivariate Cox proportional hazards models were used to determine the association vitamin D and OS. Results: The measured PFS and OS of the patients were 260.7 weeks and 323.6 weeks, respectively. Receiver operat- ing characteristic analysis revealed that vitamin D level <12.5 ng/dl was determined as the optimal cutoff value for OS prediction with the sensitivity of 62.5% and specificity of 58.5% (AUC:0.633, p=0.01). After adjustment for the number of covariates, multivariate Cox regression analysis identified a lower vitamin D level as an independent predictive factor of worse OS (hazard ratio: 2.774, 95% confidence interval: 1.486–5.178, p=0.001). Conclusion: Our results suggested that vitamin D level might function as an independent predictor in patients with bladder cancer before systemic treatment.