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https://hdl.handle.net/11499/5221
Title: | Urine and serum free IGF-1 levels in patients with bladder cancer: A brief report | Authors: | Serel, T.A. Turan, Tahir Soyupek, S. Aybek, Zafer Perk, H. |
Keywords: | Bladder cancer Free insulin-like growth factor-1 somatomedin C adult article bladder cancer bladder carcinogenesis blood level cell proliferation clinical article controlled study correlation coefficient covariance epithelium cell histopathology human priority journal radioimmunoassay rank sum test statistical analysis urine level Humans Insulin-Like Growth Factor I Middle Aged Urinary Bladder Neoplasms |
Abstract: | Insulin-like growth factor (IGF)-1, a mitogenic and anti-apoptotic peptide, can affect the proliferation of epithelial cells, and is thought to play a role in cancer development. The free IGF-1 represents the biologically active fraction of IGF-1. We hypothesised that there is a difference in free IGF-1 levels in the urine and serum from patients with TCC and normal subjects. Urine and blood samples were collected from 30 cases of superficial TCC and an equal number control subjects without malignancy. Free IGF-1 levels were measured in duplicate by radioimmunoassay. Specimens of bladder carcinoma were staged histopathologically using the Mostoffi grading system. Statistical analyses were performed using the Mann-Whitney U-test, Pearson correlation and covariate analysis. There was no significant difference in urine and serum free IGF-1 levels between the two groups. The correlation between urine and serum free IGF-1 levels and age was not significant. There was also no significant relationship between free IGF-1 levels and histopathological grading. The results of this pilot study reveal that the free IGF-1 level does not help predict tumour marker in the patients with bladder cancer. | URI: | https://hdl.handle.net/11499/5221 https://doi.org/10.1007/s00240-003-0335-0 |
ISSN: | 0300-5623 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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