Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5248
Title: Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease
Authors: Fenkci, Veysel
Fenkci, Semin Melahat
Yilmazer, M.
Serteser, M.
Keywords: Antioxidant status
Cardiovascular risk
Oxidative stress
PCOS
androgen
C reactive protein
carbonyl derivative
gonadotropin
high density lipoprotein
hormone
insulin
lipid
adult
antioxidant activity
article
biometry
blood sampling
cardiovascular disease
cardiovascular risk
clinical article
clinical study
controlled study
correlation analysis
female
homeostasis
human
insulin blood level
insulin resistance
ovary polycystic disease
oxidative stress
priority journal
statistical significance
Publisher: Elsevier Inc.
Abstract: Objective: To determine oxidative stress by the level of protein carbonyls and total antioxidant status (TAOS), and whether oxidative stress is associated with increased risk of cardiovascular disease in women with polycystic ovary syndrome (PCOS). Design: Controlled clinical study. Setting: University hospital. Patient(s): Thirty women with PCOS and 31 healthy control women. Intervention(s): Biometric measures and blood samples collection. Main Outcome Measure(s): C-reactive protein (CRP), lipid fractions, glucose, protein carbonyls, insulin, and other hormone (gonadotropins, androgens) levels and TOAS were measured. The estimate of insulin resistance was calculated by homeostasis model assessment (HOMA-R). Result(s): The women with PCOS had significantly higher serum fasting insulin, CRP, protein carbonyl levels, HOMA-R, LH levels, and LH/FSH ratios than healthy women. However, TAOS was significantly lower in women with PCOS. TAOS was negatively correlated with fasting insulin, HOMA-R, CRP, and protein carbonyls. Fasting insulin was positively correlated with protein carbonyls. High density lipoprotein (HDL) was inversely associated with fasting insulin, HOMA-R, and protein carbonyls. Conclusion(s): Increased oxidative stress and decreased antioxidant capacity may contribute to the increased risk of cardiovascular disease in women with PCOS, in addition to known risk factors such as insulin resistance, hypertension, central obesity, and dyslipidemia. © 2003 by American Society for Reproductive Medicine.
URI: https://hdl.handle.net/11499/5248
https://doi.org/10.1016/S0015-0282(03)00571-5
ISSN: 0015-0282
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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