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https://hdl.handle.net/11499/5249
Title: | Effects of pentoxifylline on alcohol-induced gastric injury and acid secretion in rats | Authors: | Yönetçi, Nadir. Kösekli, Mehmet Ali. Özütemiz, A.Ö. Karaoğlu, A.Ö. Oruç, N. Erkuş, M. Tanyalçin, T. |
Keywords: | Alcohol-induced gastritis Gastric acid secretion Malondialdehyde Nitric oxide Pentoxifylline Prostaglandin alcohol glutathione glutathione disulfide indometacin malonaldehyde n(g) nitroarginine nitric oxide pentoxifylline prostaglandin animal experiment animal model animal tissue article controlled study drug effect male microscopy nonhuman priority journal prostaglandin synthesis rat stomach acid secretion stomach mucosa injury stomach pH stomach protection |
Publisher: | Kluwer Academic/Plenum Publishers | Abstract: | We aimed to evaluate the protective effects of pentoxifylline on alcohol-induced gastric injury, its relation with nitric oxide and prostaglandin synthesis, as well as gastric acidity in rats. Acute gastric mucosal injury was induced by intragastric infusion of 2 ml 98% alcohol. Pentoxifylline was given at 100 mg/kg intraperitoneally. Indomethacin and N G -nitro-L arginine were used to inhibit prostaglandin and nitric oxide synthesis, respectively. Macroscopic and microscopic gastric injuries were evaluated. Gastric pH, tissue malondialdehyde levels, oxidized and reduced glutathion (GSSG/GSH) levels, and effects of pentoxifylline on gastric acid output were measured. Pentoxifylline pretreatment significantly reduced macroscopic and microscopic gastric injury. Malondialdehyde level was lower in pentoxifylline treated rats (351.1 ± 94.1 nmol/g vs 624.3 ± 234.2 nmol/g). Pentoxifylline has a protective role on alcohol-induced gastric mucosal injury in rats. This effect is not related to synthesis of prostaglandins and changes in gastric acidity but does seem to be related to nitric oxide-mediated pathways. In contrast, pentoxifylline increases gastric acid output significantly. | URI: | https://hdl.handle.net/11499/5249 https://doi.org/10.1023/A:1024290615796 |
ISSN: | 0163-2116 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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