Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5249
Title: Effects of pentoxifylline on alcohol-induced gastric injury and acid secretion in rats
Authors: Yönetçi, Nadir.
Kösekli, Mehmet Ali.
Özütemiz, A.Ö.
Karaoğlu, A.Ö.
Oruç, N.
Erkuş, M.
Tanyalçin, T.
Keywords: Alcohol-induced gastritis
Gastric acid secretion
Malondialdehyde
Nitric oxide
Pentoxifylline
Prostaglandin
alcohol
glutathione
glutathione disulfide
indometacin
malonaldehyde
n(g) nitroarginine
nitric oxide
pentoxifylline
prostaglandin
animal experiment
animal model
animal tissue
article
controlled study
drug effect
male
microscopy
nonhuman
priority journal
prostaglandin synthesis
rat
stomach acid secretion
stomach mucosa injury
stomach pH
stomach protection
Publisher: Kluwer Academic/Plenum Publishers
Abstract: We aimed to evaluate the protective effects of pentoxifylline on alcohol-induced gastric injury, its relation with nitric oxide and prostaglandin synthesis, as well as gastric acidity in rats. Acute gastric mucosal injury was induced by intragastric infusion of 2 ml 98% alcohol. Pentoxifylline was given at 100 mg/kg intraperitoneally. Indomethacin and N G -nitro-L arginine were used to inhibit prostaglandin and nitric oxide synthesis, respectively. Macroscopic and microscopic gastric injuries were evaluated. Gastric pH, tissue malondialdehyde levels, oxidized and reduced glutathion (GSSG/GSH) levels, and effects of pentoxifylline on gastric acid output were measured. Pentoxifylline pretreatment significantly reduced macroscopic and microscopic gastric injury. Malondialdehyde level was lower in pentoxifylline treated rats (351.1 ± 94.1 nmol/g vs 624.3 ± 234.2 nmol/g). Pentoxifylline has a protective role on alcohol-induced gastric mucosal injury in rats. This effect is not related to synthesis of prostaglandins and changes in gastric acidity but does seem to be related to nitric oxide-mediated pathways. In contrast, pentoxifylline increases gastric acid output significantly.
URI: https://hdl.handle.net/11499/5249
https://doi.org/10.1023/A:1024290615796
ISSN: 0163-2116
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

2
checked on Sep 30, 2024

WEB OF SCIENCETM
Citations

1
checked on Sep 30, 2024

Page view(s)

66
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.