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https://hdl.handle.net/11499/5252
Title: | Relation of intra-abdominal fat distribution to metabolic disorders in nonobese patients with polycystic ovary syndrome | Authors: | Yıldırım, Başak Sabir, Nuran Kaleli, Babur |
Keywords: | Fat distribution Polycystic ovary syndrome Ultrasonography Visceral fat cholesterol estradiol follitropin glucose high density lipoprotein insulin lipid low density lipoprotein luteinizing hormone prasterone sulfate prolactin testosterone triacylglycerol abdomen adult area under the curve article body fat body mass cholesterol blood level clinical article controlled study correlation analysis diet restriction dyslipidemia echography female glucose blood level glucose intolerance glucose metabolism glucose tolerance hormone blood level human hyperinsulinemia insulin blood level insulin sensitivity lean body weight lipid analysis lipid metabolism lipid storage metabolic disorder metabolism multiple regression oral glucose tolerance test ovary polycystic disease priority journal subcutaneous fat triacylglycerol blood level |
Publisher: | Elsevier Inc. | Abstract: | Objective: To investigate the relation between intra-abdominal fat distribution and metabolic disorders in nonobese patients with the polycystic ovary syndrome (PCOS). Design: Prospective case-control study. Setting: University-based hospital. Patient(s): Thirty nonobese patients with PCOS and 30 lean women with regular menstrual cycles (controls). All participants had a body mass index < 25kg/m2. Main Outcome Measure(s): Subcutaneous and intra-abdominal visceral and preperitoneal fat thicknesses were assessed by ultrasonography. Glucose tolerance and insulin sensitivity were evaluated by standard 75-g oral glucose tolerance test and area-under-the-curve analysis. Serum hormones and lipid profile were measured. Result(s): The mean preperitoneal and visceral fat thicknesses were significantly greater in nonobese patients with PCOS. Subcutaneous fat mass was similar between the PCOS and control groups. Nonobese patients with PCOS had glucose intolerance, hyperinsulinemia, and dyslipidemia, manifested by high serum levels of triglyceride, total cholesterol, and high-density lipoprotein (HDL) levels and low serum low-density lipoprotein (LDL) levels. No correlation existed between subcutaneous fat thickness and the metabolic variables in nonobese patients with PCOS. However, serum triglyceride levels correlated with visceral fat and preperitoneal fat thickness. The mean HDL level correlated negatively with visceral fat and preperitoneal fat thickness. The area under the curve for insulin and mean fasting insulin levels correlated positively with visceral fat thickness. In multiple regression analysis, visceral fat thickness contributed significantly to high serum triglyceride and fasting insulin levels. Conclusion(s): Intra-abdominal preperitoneal and visceral fat accumulation may contribute to the development of glucose and lipid metabolism disorders in nonobese patients with PCOS. © 2003 by American Society for Reproductive Medicine. | URI: | https://hdl.handle.net/11499/5252 https://doi.org/10.1016/S0015-0282(03)00265-6 |
ISSN: | 0015-0282 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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