Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5252
Title: Relation of intra-abdominal fat distribution to metabolic disorders in nonobese patients with polycystic ovary syndrome
Authors: Yıldırım, Başak
Sabir, Nuran
Kaleli, Babur
Keywords: Fat distribution
Polycystic ovary syndrome
Ultrasonography
Visceral fat
cholesterol
estradiol
follitropin
glucose
high density lipoprotein
insulin
lipid
low density lipoprotein
luteinizing hormone
prasterone sulfate
prolactin
testosterone
triacylglycerol
abdomen
adult
area under the curve
article
body fat
body mass
cholesterol blood level
clinical article
controlled study
correlation analysis
diet restriction
dyslipidemia
echography
female
glucose blood level
glucose intolerance
glucose metabolism
glucose tolerance
hormone blood level
human
hyperinsulinemia
insulin blood level
insulin sensitivity
lean body weight
lipid analysis
lipid metabolism
lipid storage
metabolic disorder
metabolism
multiple regression
oral glucose tolerance test
ovary polycystic disease
priority journal
subcutaneous fat
triacylglycerol blood level
Publisher: Elsevier Inc.
Abstract: Objective: To investigate the relation between intra-abdominal fat distribution and metabolic disorders in nonobese patients with the polycystic ovary syndrome (PCOS). Design: Prospective case-control study. Setting: University-based hospital. Patient(s): Thirty nonobese patients with PCOS and 30 lean women with regular menstrual cycles (controls). All participants had a body mass index < 25kg/m2. Main Outcome Measure(s): Subcutaneous and intra-abdominal visceral and preperitoneal fat thicknesses were assessed by ultrasonography. Glucose tolerance and insulin sensitivity were evaluated by standard 75-g oral glucose tolerance test and area-under-the-curve analysis. Serum hormones and lipid profile were measured. Result(s): The mean preperitoneal and visceral fat thicknesses were significantly greater in nonobese patients with PCOS. Subcutaneous fat mass was similar between the PCOS and control groups. Nonobese patients with PCOS had glucose intolerance, hyperinsulinemia, and dyslipidemia, manifested by high serum levels of triglyceride, total cholesterol, and high-density lipoprotein (HDL) levels and low serum low-density lipoprotein (LDL) levels. No correlation existed between subcutaneous fat thickness and the metabolic variables in nonobese patients with PCOS. However, serum triglyceride levels correlated with visceral fat and preperitoneal fat thickness. The mean HDL level correlated negatively with visceral fat and preperitoneal fat thickness. The area under the curve for insulin and mean fasting insulin levels correlated positively with visceral fat thickness. In multiple regression analysis, visceral fat thickness contributed significantly to high serum triglyceride and fasting insulin levels. Conclusion(s): Intra-abdominal preperitoneal and visceral fat accumulation may contribute to the development of glucose and lipid metabolism disorders in nonobese patients with PCOS. © 2003 by American Society for Reproductive Medicine.
URI: https://hdl.handle.net/11499/5252
https://doi.org/10.1016/S0015-0282(03)00265-6
ISSN: 0015-0282
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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