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https://hdl.handle.net/11499/5261
Title: | The role of elevated liver transaminase levels in children with blunt abdominal trauma | Authors: | Karaduman, Dolunay Sarıoğlu-Büke, Akile Kılıç, İlknur Gürses, Ercan |
Keywords: | alanine aminotransferase aminotransferase aspartate aminotransferase abdominal blunt trauma accuracy alanine aminotransferase blood level article aspartate aminotransferase blood level child correlation analysis data analysis evaluation female hemodynamics human injury scale liver liver injury major clinical study male multiple trauma prediction priority journal prospective study radiodiagnosis statistical significance Abdominal Injuries Alanine Transaminase Aspartate Aminotransferases Biological Markers Child Child, Preschool Enzyme Tests Female Humans Liver Liver Function Tests Male Physical Examination Wounds, Nonpenetrating |
Abstract: | The role of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) levels on intra-abdominal injury in children has not been adequately studied. In this report, the accuracy of these tests in predicting the degree and extend of intra-abdominal and hepatic injury in children with blunt abdominal trauma was investigated. Eighty-seven haemodynamically stable children with multiple trauma were prospectively evaluated. The SGOT and SGPT of patients with and without abdominal trauma (Groups I and II) were compared. Patients with and without radiologically verified intra-abdominal injury were further compared (Groups Ib and Ia). There was significant difference in SGOT and SGPT levels of Groups I and II. SGOT and SGPT levels were 333.6±283.8 and, 197.5±192.5U/l, respectively in Group Ib; but 84.2±55.9, 43±29.8U/l in Group Ia (P<0.001). In all patients with radiologically detected intra-abdominal pathology SGOT and SGPT levels were above 110.5 and 63.5U/l, respectively. In patients with hepatic injury SGOT level was above 500U/l and, SGPT level was above 300U/l. Statistically significant positive correlation was found between radiologically detected intra-abdominal pathology and increased SGOT (above 110.5U/l) and SGPT (above 63.5U/l) levels (P<0.05). These data indicated that the SGOT and SGPT levels were significantly higher in patients with intra-abdominal injury even in the absence of hepatic injury. We suggest that liver function tests may be used as screening tests in children with blunt abdominal trauma in addition to physical abdominal examination. A sudden rise up to 110.5U/l in SGOT and 63.5U/l in SGPT indicate an intra-abdominal injury and severe hepatic injury should be suspected with higher levels of SGOT and SGPT. © 2003 Elsevier Science Ltd. All rights reserved. | URI: | https://hdl.handle.net/11499/5261 https://doi.org/10.1016/S0020-1383(02)00188-2 |
ISSN: | 0020-1383 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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