Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5262
Title: Secretory meningiomas: Report of clinical, immunohistochemical findings in 12 cases and review of literature
Authors: Çolakoglu, Nagihan
Demirtaş, E.
Oktar, N.
Yüntem, N.
Islekel, S.
Özdamar, N.
Keywords: HMFG-2
Immunohistochemistry
Secretory meningioma
Ubiquitin
alpha 1 antitrypsin
CA 125 antigen
carcinoembryonic antigen
cytokeratin
epithelial membrane antigen
estrogen receptor
globulin
Ki 67 antigen
milk fat globulin 2
progesterone receptor
ubiquitin
unclassified drug
tumor marker
tumor protein
adult
aged
article
cancer recurrence
cell inclusion
cellular distribution
clinical article
clinical feature
controlled study
disease classification
female
follow up
histopathology
human
immunohistochemistry
male
meningioma
neurosurgery
staining
chemistry
classification
comparative study
computer assisted tomography
enzyme immunoassay
middle aged
pathology
review
Adult
Aged
Female
Humans
Immunoenzyme Techniques
Male
Meningeal Neoplasms
Meningioma
Middle Aged
Neoplasm Proteins
Tomography, X-Ray Computed
Tumor Markers, Biological
Abstract: Secretory meningiomas are a rare meningioma subtype. Among meningiomas, the frequency of secretory meningiomas is 1.6%. Unlike other meningioma types, most of the patients were female (ratio 3:1). No recurrence was reported during the 24-180 months follow-up period of our secretory meningiomas in which, a low level of 0.3% Ki-67 proliferative index was reported. In this meningioma subtype, the percentage of cases with positive progesterone receptor is 33%. With carcinoembryonic antigen, cytokeratin and epithelial membrane antigen, in all the cases positivity was observed in both, the inclusions and the cells surrounding them. With human milk fat globulin 2, a high ratio (92%) of positivity was observed. Majority of the cases were negative with CA125, only three of the cases had suspicious positivity. Distribution of inclusions was irregular and their positive reactions showed varying staining features. Positivity with alpha-1-antitripsin was seen not only in the inclusions but also in some meningothelial cells as well. Ubiquitin was positive in inclusions of the 83% of cases. Staining features of the inclusions pointed out the possibility of them being in a varying age and/or content. Secretory meningiomas are a different type compared to other meningiomas, not only with their histological features but also with their clinical features as well.
URI: https://hdl.handle.net/11499/5262
https://doi.org/10.1023/A:1023319407645
ISSN: 0167-594X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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