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https://hdl.handle.net/11499/5262
Title: | Secretory meningiomas: Report of clinical, immunohistochemical findings in 12 cases and review of literature | Authors: | Çolakoglu, Nagihan Demirtaş, E. Oktar, N. Yüntem, N. Islekel, S. Özdamar, N. |
Keywords: | HMFG-2 Immunohistochemistry Secretory meningioma Ubiquitin alpha 1 antitrypsin CA 125 antigen carcinoembryonic antigen cytokeratin epithelial membrane antigen estrogen receptor globulin Ki 67 antigen milk fat globulin 2 progesterone receptor ubiquitin unclassified drug tumor marker tumor protein adult aged article cancer recurrence cell inclusion cellular distribution clinical article clinical feature controlled study disease classification female follow up histopathology human immunohistochemistry male meningioma neurosurgery staining chemistry classification comparative study computer assisted tomography enzyme immunoassay middle aged pathology review Adult Aged Female Humans Immunoenzyme Techniques Male Meningeal Neoplasms Meningioma Middle Aged Neoplasm Proteins Tomography, X-Ray Computed Tumor Markers, Biological |
Abstract: | Secretory meningiomas are a rare meningioma subtype. Among meningiomas, the frequency of secretory meningiomas is 1.6%. Unlike other meningioma types, most of the patients were female (ratio 3:1). No recurrence was reported during the 24-180 months follow-up period of our secretory meningiomas in which, a low level of 0.3% Ki-67 proliferative index was reported. In this meningioma subtype, the percentage of cases with positive progesterone receptor is 33%. With carcinoembryonic antigen, cytokeratin and epithelial membrane antigen, in all the cases positivity was observed in both, the inclusions and the cells surrounding them. With human milk fat globulin 2, a high ratio (92%) of positivity was observed. Majority of the cases were negative with CA125, only three of the cases had suspicious positivity. Distribution of inclusions was irregular and their positive reactions showed varying staining features. Positivity with alpha-1-antitripsin was seen not only in the inclusions but also in some meningothelial cells as well. Ubiquitin was positive in inclusions of the 83% of cases. Staining features of the inclusions pointed out the possibility of them being in a varying age and/or content. Secretory meningiomas are a different type compared to other meningiomas, not only with their histological features but also with their clinical features as well. | URI: | https://hdl.handle.net/11499/5262 https://doi.org/10.1023/A:1023319407645 |
ISSN: | 0167-594X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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