Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5272
Title: Effect of copper overload together with ethanol uptake on hippocampal neurons
Authors: Turgut, Günfer
Akdogan, Ilgaz
Adıgüzel, Esat
Genç, Osman
Keywords: Copper
Ethanol
Hippocampus
Rat
Stereology
alcohol
copper
trace element
alcohol consumption
animal cell
animal food
animal tissue
article
cell count
controlled study
craniotomy
frozen section
hippocampus
intoxication
nerve cell
nerve cell necrosis
neurotoxicity
nonhuman
pyramidal nerve cell
randomization
rat
Animals
Cell Count
Central Nervous System Depressants
Environmental Pollutants
Pyramidal Cells
Rats
Rats, Wistar
Abstract: Copper is an essential trace element which forms an integral component of many enzymes. While trace amounts of copper are needed to sustain life, excess copper is extremely toxic in the brain. Also, ethanol intake causes morphological changes in the brain. The present study aims to investigate effects of copper overload with ethanol intake in hippocampal neuron numbers of rat brain. Control and experimental group of rats (n=6 for each group) were fed ad libitum. Experimental group were given ethanol with copper in drinking water each day for ten days. Control group animals were given only drinking water during this period. Afterwards, animals were decapitated and their brains were removed by craniotomy. Frozen brains were cut by a cryostat. Sections collected via systematic random sampling were stained with hematoxylin and eosin. On microscopic images obtained from pyramidal cell layers in hippocampus, total neuron numbers were estimated using the optical fractionator method. We observed that pyramidal neuron numbers in the subdivisions of hippocampus were significantly lower in the experimental group than in the control group. These results suggest that copper overdose with ethanol intake can cause neuronal loss in hippocampus of rat brain. © 2003 Tohoku University Medical Press.
URI: https://hdl.handle.net/11499/5272
https://doi.org/10.1620/tjem.199.239
ISSN: 0040-8727
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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