Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5279
Title: Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: Effects of trimetazidine in rats
Authors: Oguzhanoglu, Attila
Kurt, T.
Ortaç, R.
Turman, B.
Keywords: Brain damage
Evoked potential
Global ischaemia
Trimetazidine
s 5016
trimetazidine
animal experiment
animal model
animal tissue
article
brain ischemia
cell damage
controlled study
drug effect
evoked somatosensory response
hippocampus
histopathology
neuroprotection
nonhuman
rat
reperfusion injury
Animals
Brain Ischemia
Cell Death
Chi-Square Distribution
Disease Models, Animal
Evoked Potentials, Somatosensory
Hippocampus
Neuroprotective Agents
Rats
Rats, Sprague-Dawley
Reperfusion Injury
Statistics, Nonparametric
Vasodilator Agents
Abstract: We studied the protective effects of trimetazidine (TMZ) on brain damage by means of somatosensory evoked potentials (SEP) in rats. The TMZ group did not show any statistically significant difference from the control group with respect to SEPs. However, the percentage of cells with ischaemic cell damage in hippocampal regions was significantly smaller in the TMZ group than the control group. Trimetazidine reduced the number of damaged cells in the cerebral tissue during the ischaemia-reperfusion damage. It was suggested that higher doses of trimetazidine may further reduce the number of cells with ischaemic damage.
URI: https://hdl.handle.net/11499/5279
https://doi.org/10.1080/00207450390162209
ISSN: 0020-7454
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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