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https://hdl.handle.net/11499/5279
Title: | Somatosensory evoked potential and histopathological investigations in ischaemia-induced brain damage: Effects of trimetazidine in rats | Authors: | Oguzhanoglu, Attila Kurt, T. Ortaç, R. Turman, B. |
Keywords: | Brain damage Evoked potential Global ischaemia Trimetazidine s 5016 trimetazidine animal experiment animal model animal tissue article brain ischemia cell damage controlled study drug effect evoked somatosensory response hippocampus histopathology neuroprotection nonhuman rat reperfusion injury Animals Brain Ischemia Cell Death Chi-Square Distribution Disease Models, Animal Evoked Potentials, Somatosensory Hippocampus Neuroprotective Agents Rats Rats, Sprague-Dawley Reperfusion Injury Statistics, Nonparametric Vasodilator Agents |
Abstract: | We studied the protective effects of trimetazidine (TMZ) on brain damage by means of somatosensory evoked potentials (SEP) in rats. The TMZ group did not show any statistically significant difference from the control group with respect to SEPs. However, the percentage of cells with ischaemic cell damage in hippocampal regions was significantly smaller in the TMZ group than the control group. Trimetazidine reduced the number of damaged cells in the cerebral tissue during the ischaemia-reperfusion damage. It was suggested that higher doses of trimetazidine may further reduce the number of cells with ischaemic damage. | URI: | https://hdl.handle.net/11499/5279 https://doi.org/10.1080/00207450390162209 |
ISSN: | 0020-7454 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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