Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52792
Title: Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant Gram-Negative Bacteria in a Pediatric Intensive Care Unit
Authors: Deniz, Melis
Şenol, Hande
Erat, Tugba
Ari, Hatice Feray
Altug, Umit
Kiral, Eylem
Parlak, Kerim
Ozcinar, Hadice
Keywords: ventilator-associated pneumonia
pediatric intensive care unit
antibiotic resistance
antimicrobial stewardship
carbapenem-resistant
Acinetobacter-Baumannii
Risk-Factors
Multidrug-Resistant
Drug-Resistant
Publisher: Georg Thieme Verlag Kg
Abstract: We aimed to analyze risk factors of ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR), pan-drug-resistant (PDR), and extensively drug-resistant (XDR) gram-negative bacteria (GNB) in a pediatric intensive care unit (PICU). This retrospective study evaluated pediatric patients diagnosed with VAP at a tertiary referral hospital. Of the 46 children in the present study, 40 (86.9%) had VAP caused by MDR-, XDR-, and PDR-GNB. Most patients (60.9%) had spent >28 days in the PICU at the time of diagnosis. Respiratory failure necessitating PICU admission was associated with XDR infection-induced VAP ( p = 0.034). High rates of prior broad-spectrum antibiotic use were observed in patients with XDR GNB-induced VAP. VAP induced by MDR-, XDR-, and PDR-GNB occurred more frequently than that caused by drug-susceptible GNB in PICU patients. Long stays for more than 28 days in the PICU and past use of broad-spectrum antibiotics can lead to the development of XDR-GNB-induced VAP. The high antibiotic resistance rates detected in our study highlight the importance of strict infection control measures and antimicrobial stewardship programs in PICUs.
Description: Article; Early Access
URI: https://doi.org/10.1055/s-0043-1772818
https://hdl.handle.net/11499/52792
ISSN: 2146-4618
2146-4626
Appears in Collections:Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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