Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52798
Title: The relationship of immunohistochemical SOX-2 staining with histopathological diagnosis in patients with abnormal colposcopic findings
Authors: Atıgan, Ayhan
Kılıç, Derya
Arman Karakaya, Yeliz
Gök, Soner
Güler, Ömer Tolga
Keywords: Immunohistochemistry
SOX-2
Cervical intraepithelial neoplasia (CIN)
HPV
Margin Involvement
P16 Protein
Expression
Disease
Cancer
Publisher: Springer
Abstract: This study aimed to analyze immunohistochemical staining and pathological data in cervical intraepithelial neoplasia (CIN) and squamous cell cervical carcinoma (SCC) with abnormal colposcopic findings. A histopathological evaluation of 45 low-grade squamous lesions (LSILs), 177 high-grade squamous lesions (HSILs) and 16 SCC biopsy materials from existing slides was obtained from blocks obtained from the archive. In addition, SOX-2 immunohistochemical staining was evaluated. The mean age of the HSIL group was 43.20 & PLUSMN; 8.97 years, younger than the mean age of the LSIL group of 51.62 & PLUSMN; 9.64 years (p = 0.000). There was no difference between the groups regarding the method of biopsy (p > 0.05). Endocervical gland involvement was not observed in the LSIL group, but was observed in 66 (37.3%) biopsy materials in the HSIL group (p = 0.000). There was a difference between the groups in terms of the level of CIN at the surgical margin (p = 0.000). Ki-67, SOX-2 staining percentage and p16INK4a positivity were higher in the HSIL group than in the LSIL group (respectively, 67.57 & PLUSMN; 19.10 vs. 14.62 & PLUSMN; 7.11, p = 0.000; 27.72 & PLUSMN; 31.56 vs. 10.09 & PLUSMN; 15.38, p = 0.003; 66 (82.5%) vs. 8 (44.4%), p = 0.001). While there was no difference in SOX-2 intensity between the HSIL and LSIL groups (p > 0.05), it was statistically significantly higher in the SCC group (p = 0.000), as was the percentage of SOX-2 (p = 0.000). We have shown that p16INK4a and SOX-2 staining is useful, in addition to Ki-67 immunostaining, which is widely used for SCC, which is one of the preventable cancer types. In addition, SOX-2 may provide a glimmer of hope in the development of SCC treatment modalities, especially since it is aggressively elevated in SCC rather than CIN lesions.
Description: Article; Early Access
URI: https://doi.org/10.1007/s00418-023-02230-4
https://hdl.handle.net/11499/52798
ISSN: 0948-6143
1432-119X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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