Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5280
Title: Role of free radicals in peptic ulcer and gastritis
Authors: Demir, Süleyman
Yılmaz, Mustafa
Köseoğlu, M.
Akalin, N.
Aslan, D.
Aydin, A.
Keywords: Gastritis
Glutathione
Lipid peroxidation
Malondialdehyde
Peptic ulcer
antioxidant
free radical
glutathione
malonaldehyde
reactive oxygen metabolite
article
clinical article
controlled study
gastritis
Helicobacter infection
Helicobacter pylori
human
human tissue
lipid peroxidation
membrane damage
oxidative stress
peptic ulcer
stomach biopsy
stomach mucosa
Biological Markers
Case-Control Studies
Dyspepsia
Female
Free Radicals
Gastric Mucosa
Gastroscopy
Humans
Lipid Peroxidation
Male
Probability
Prognosis
Sampling Studies
Sensitivity and Specificity
Stomach Ulcer
Abstract: Background/aims: It has been suggested that the free radicals are closely related with peptic ulcer disease and gastritis. Although many studies have been undertaken to clarify the role of oxygen-derived free radicals, most of them were carried out in animal models. The aim of this study was to assess the reactive oxygen species activity and the damage in Helicobacter pyloriinfected gastric mucosa in humans. Methods: In a total group of 42, there were fifteen cases of peptic ulcer, 14 cases of gastritis and 12 control subjects. Measurement of gastric mucosal malondialdehyde concentrations, which is the end - product of lipid peroxidation, was used to assess oxidative damage to membranes in patients with peptic ulcer and gastritis. Mucosal reduced glutathione glutathione concentrations were also measured in order to study whether reactive oxygen species generation affects levels of the antioxidant peptide, malondialdehyde and glutathione content was then measured in biopsies taken from the gastric antrum. Results: Tissue levels of glutathione were significantly (p <0.001) and malondialdehyde was higher (p<0.001) in patients with peptic ulcer compared to controls. In patients with gastritis, glutathione was also lower (p<0.001) and malondialdehyde higher (p<0.01). Conclusions: Depletion of gastric mucosal glutathione in cases with H.pylori positive peptic ulcer and gastritis may be caused by accumulation of free radicals that can initiate membrane damage by lipid peroxidation.
URI: https://hdl.handle.net/11499/5280
ISSN: 1300-4948
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

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