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Title: | Role of free radicals in peptic ulcer and gastritis | Authors: | Demir, Süleyman Yılmaz, Mustafa Köseoğlu, M. Akalin, N. Aslan, D. Aydin, A. |
Keywords: | Gastritis Glutathione Lipid peroxidation Malondialdehyde Peptic ulcer antioxidant free radical glutathione malonaldehyde reactive oxygen metabolite article clinical article controlled study gastritis Helicobacter infection Helicobacter pylori human human tissue lipid peroxidation membrane damage oxidative stress peptic ulcer stomach biopsy stomach mucosa Biological Markers Case-Control Studies Dyspepsia Female Free Radicals Gastric Mucosa Gastroscopy Humans Lipid Peroxidation Male Probability Prognosis Sampling Studies Sensitivity and Specificity Stomach Ulcer |
Abstract: | Background/aims: It has been suggested that the free radicals are closely related with peptic ulcer disease and gastritis. Although many studies have been undertaken to clarify the role of oxygen-derived free radicals, most of them were carried out in animal models. The aim of this study was to assess the reactive oxygen species activity and the damage in Helicobacter pyloriinfected gastric mucosa in humans. Methods: In a total group of 42, there were fifteen cases of peptic ulcer, 14 cases of gastritis and 12 control subjects. Measurement of gastric mucosal malondialdehyde concentrations, which is the end - product of lipid peroxidation, was used to assess oxidative damage to membranes in patients with peptic ulcer and gastritis. Mucosal reduced glutathione glutathione concentrations were also measured in order to study whether reactive oxygen species generation affects levels of the antioxidant peptide, malondialdehyde and glutathione content was then measured in biopsies taken from the gastric antrum. Results: Tissue levels of glutathione were significantly (p <0.001) and malondialdehyde was higher (p<0.001) in patients with peptic ulcer compared to controls. In patients with gastritis, glutathione was also lower (p<0.001) and malondialdehyde higher (p<0.01). Conclusions: Depletion of gastric mucosal glutathione in cases with H.pylori positive peptic ulcer and gastritis may be caused by accumulation of free radicals that can initiate membrane damage by lipid peroxidation. | URI: | https://hdl.handle.net/11499/5280 | ISSN: | 1300-4948 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection |
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