Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52810
Title: Histopathologic features of inflammatory fibroid polyps and risk of cancer development: a case series
Other Titles: İnflamatuar fibroid poliplerin histopatolojik özellikleri ve kanser gelişme riski: bir vaka serisi
Authors: Çomut, Erdem
Arman Karakaya, Yeliz
Çelik, Mustafa
Çallı, Demirkan, Neşe
Keywords: carcinoma
dysplasia
gastrointestinal
histopathology
Inflammatory fibroid polyp
Publisher: Pamukkale University
Abstract: Purpose: Inflammatory fibroid polyp (IFP) is seen in the gastrointestinal tract. In most cases, somatic mutations in PDGFRA gene were observed and the true neoplastic origin of this entity was understood. It is a benign mesenchymal tumor and rarely recurs. The aim of the study was to reveal the histopathologic features of our IFP cases and to investigate the risk of cancer in one case. Materials and methods: We performed a retrospective clinicopathological analysis of patients (n=12) who were reported as IFP between 2012 and 2022. Formalin-fixed, paraffin-embedded and hematoxylin-eosin (H&E)-stained slides of the cases were re-examined by two pathologists microscopically. Results: All patients were adults and ranged in age from 30 to 85. Male to female ratio was 1:2. One polyp was localized in small intestine, one in colon, and the others in stomach. Histologically, there were hyperplastic epithelial changes (7/12), low-grade (3/12), and high-grade dysplasia (1/12) accompanying IFPs. One case was associated with early gastric adenocarcinoma. Discussion: Although IFP appears as a benign mesenchymal tumor, it should be kept in mind that dysplasia and rarely carcinoma may accompany this lesion. Larger case series are needed to elucidate the mechanisms of dysplasia and carcinoma development associated with IFP. © 2023, Pamukkale University. All rights reserved.
URI: https://doi.org/10.31362/patd.1270475
https://hdl.handle.net/11499/52810
ISSN: 1309-9833
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

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