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Title: | The comparison of the suture materials on intestinal anastomotic healing: an experimental study | Other Titles: | Farklı dikiş materyallerinin bağırsak anastomoz iyileşmesi üzerine etkileri: Deneysel bir çalışma | Authors: | Uzunlu, O. Aydın, E. Çomut, E. Avcı, E. Şenol, H. |
Keywords: | Anastomotic healing anastomotic leak animal experiments surgical anastomosis suture techniques eosin hematoxylin hydroxyproline ketamine polydioxanone polyglactin polypropylene suture material xylazine polyglactin polypropylene abdominal cavity anastomosis leakage animal experiment animal tissue Article biochemical analysis cardiac puncture collagen synthesis colon anastomosis comparative study enzyme linked immunosorbent assay epithelization experimental study female granulation tissue healing histopathology inflammation intestine anastomosis intestine obstruction laparotomy neovascularization (pathology) nonhuman prospective study rat Wistar rat wound infection anastomosis animal suture Anastomosis, Surgical Animals Hydroxyproline Polyglactin 910 Polypropylenes Prospective Studies Rats Sutures |
Publisher: | Turkish Association of Trauma and Emergency Surgery | Abstract: | BACKGROUND: This experimental comparative study was to evaluate the local effects of three different suture materials on intestinal anastomosis healing. METHODS: Ethical approval was obtained from the University of Ethical Committee (E-60758568-020-176720). A prospective, experimental comparative analysis was conducted on 24 rats. They were divided into three equal groups; Group 1 underwent colonic anastomosis with Vicryl suture material, Group 2 underwent colonic anastomosis with polypropylene suture; and Group 3 underwent colonic anastomosis with polydioxanone (PDS) suture. The second operation underwent the 7th post-operative day. Adhesion score, anastomotic leakage, anastomotic bursting pressure, hydroxyproline levels, and histopathologic examination were evaluated. RESULTS: All animals survived, and no leakage, intestinal obstruction, or wound infection was observed during the experiment. The adhesion score was evaluated according to the Diamond classification and same in all groups. Median anastomotic bursting pressure was 125.75 mmHg (10–241) in the Vicryl group, 159.25 mmHg (113–190) in the polypropylene group, and 154.50 mmHg (20–212) in the PDS group. Hydroxyproline tissue concentrations were in the Vicryl group 1699.92±220.8 ng/mg (range: 1509.81–2186.47), in the polypropylene group 1126.24±607.12 ng/mg (range: 53.22–1815.63), and 1547.86±335.2 ng/mg (range: 973.66–1973.2) in PDS group. There was no difference among groups regarding the inflammatory response evaluated by histopathology. There was no statistical significance in all variables evaluated. CONCLUSION: This experimental study demonstrates that suture materials did not worsen tissue healing during intestinal anasto-mosis. Absorbable, slowly-absorbable, and non-absorbable suture materials could be used safely in every situation. © 2023, Turkish Association of Trauma and Emergency Surgery. All rights reserved. | URI: | https://doi.org/10.14744/tjtes.2023.86579 https://hdl.handle.net/11499/52820 |
ISSN: | 1306-696X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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The comparison of the suture materials.pdf | 1.44 MB | Adobe PDF | View/Open |
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