Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/52838
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dc.contributor.authorGulbay, G.-
dc.contributor.authorSecme, M.-
dc.contributor.authorMutlu, D.-
dc.date.accessioned2023-10-27T07:08:31Z-
dc.date.available2023-10-27T07:08:31Z-
dc.date.issued2023-
dc.identifier.issn1128-3602-
dc.identifier.urihttps://doi.org/10.26355/eurrev_202308_33394-
dc.identifier.urihttps://hdl.handle.net/11499/52838-
dc.description.abstractOBJECTIVE: Fusaric acid is a derivative of picolinic acid produced by some Fusarium species. In this study, we aimed to determine the mRNA expression and antiproliferative effects of fusaric acid in Ishikawa endometrium cancer cells in signal pathway genes associated with Toll-like receptors (TLRs). The effect of fusaric acid on the viability of Ishikawa cells was evaluated using XTT. PATIENTS AND METHODS: After total RNA was isolated from control and dose group cells, cDNA synthesis was performed, and mRNA expression changes of genes involved in the Toll-like signaling pathway were evaluated by real-time reverse-transcription polymerase chain reaction (RT-PCR). RESULTS: The decrease in viability of Ishikawa cells was observed in a time- and dose-dependent manner. The inhibitory concentration (IC50) dose of fusaric acid at the 72nd hour in the Ishikawa cell line was 142.81 µM. When the dose group treated with 125 µM fusaric acid at the 72nd hour was compared with the control group, significantly decreased toll-like receptor 1 (TLR1), TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, and Myeloid differentiation primary response protein 88 (MYD88) gene expressions were observed. CONCLUSIONS: Fusaric acid inhibits cell proliferation and downregulates Toll-like receptors pathway gene expression in Ishikawa endometrial cancer cells. © 2023 Verduci Editore s.r.l. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherVerduci Editore s.r.len_US
dc.relation.ispartofEuropean Review for Medical and Pharmacological Sciencesen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell proliferationen_US
dc.subjectEndometrial canceren_US
dc.subjectFusaric aciden_US
dc.subjectIshikawa cell lineen_US
dc.subjectToll-like signaling pathwayen_US
dc.subjectfusaric aciden_US
dc.subjectmessenger RNAen_US
dc.subjectcell proliferationen_US
dc.subjectendometriumen_US
dc.subjectendometrium tumoren_US
dc.subjectfemaleen_US
dc.subjectgeneticsen_US
dc.subjecthumanen_US
dc.subjectCell Proliferationen_US
dc.subjectEndometrial Neoplasmsen_US
dc.subjectEndometriumen_US
dc.subjectFemaleen_US
dc.subjectFusaric Aciden_US
dc.subjectHumansen_US
dc.subjectRNA, Messengeren_US
dc.titleFusaric acid inhibits cell proliferation and downregulates expressions of toll-like receptors pathway genes in Ishikawa endometrial cancer cellsen_US
dc.typeArticleen_US
dc.identifier.volume27en_US
dc.identifier.issue16en_US
dc.identifier.startpage7431en_US
dc.identifier.endpage7436en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.26355/eurrev_202308_33394-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid55217816900-
dc.authorscopusid56499294100-
dc.authorscopusid58563700700-
dc.identifier.pmid37667919en_US
dc.identifier.scopus2-s2.0-85169848197en_US
dc.identifier.wosWOS:001076331800004en_US
dc.institutionauthor-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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