Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5287
Title: Mal de Meleda: A new geographical localization in Anatolia
Authors: Ergin, Şeniz
Şanli Erdogan, Berna
Aktan, Şebnem
Keywords: Anatolia
Hereditary palmoplantar keratoderma
Mal de Meleda
adolescent
adult
article
child
clinical article
clinical examination
clinical feature
controlled study
edema
familial disease
female
finger malformation
foot disease
foot sole
hand disease
hand palm
health care planning
human
hyperhidrosis
infant
interview
keratosis palmoplantaris
mal de meleda
male
pedigree
prevalence
priority journal
Turkey (republic)
Adolescent
Adult
Child
Child, Preschool
Consanguinity
Female
Humans
Infant
Keratoderma, Palmoplantar
Male
Middle Aged
Pedigree
Turkey
Abstract: Background: Mal de Meleda (MDM) is an autosomal recessive form of palmoplantar keratoderma first described on the Dalmatian island of Meleda. MDM has been observed in many other countries so that the origin of the MDM gene may be elsewhere than in Meleda. Objective: After identification of the first MDM patient during a medical visit, a study was planned to reveal other families with MDM in the Köprüçay region in Anatolia. Methods: The patient was interviewed with a questionnaire including a pedigree drawing. All the subsequent cases reported to be of MDM were visited for clinical examination and pedigree drawings. Results: Thirty-nine patients, 8 families and 2 additional cases with MDM were identified in a 50-km(2)mountainous region in Köprüçay canyon in Anatolia. The prevalent clinical features were nail involvement (80%), 'glove-and-sock' distribution of the keratoderma (60%), edema on the hands/feet (60%), conical tapering of the fingertips (60%) and hyperhidrosis on the palms and soles (50%). Conclusion: To our knowledge, this is the largest series reported. The relationship between the patients in Meleda and those in Anatolia awaits discovery by further researches that will be carried out with the collaboration of dermatology, genetics and medical history departments. Copyright © 2003 S. Karger AG, Basel.
URI: https://hdl.handle.net/11499/5287
https://doi.org/10.1159/000068464
ISSN: 1018-8665
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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