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https://hdl.handle.net/11499/52870
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DC Field | Value | Language |
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dc.contributor.author | Ugurlu, Erhan | - |
dc.contributor.author | Metin, Melis | - |
dc.contributor.author | Cetin, Nazlı | - |
dc.contributor.author | Kilicarslan, Emel | - |
dc.contributor.author | Degirmencioglu, Serkan | - |
dc.contributor.author | Sengoz, Tarık | - |
dc.contributor.author | Akbudak, İlknur Hatice | - |
dc.contributor.author | Gokoz Dogu, Gamze | - |
dc.contributor.author | Aydoğmuş, Ümit | - |
dc.date.accessioned | 2023-10-27T07:09:33Z | - |
dc.date.available | 2023-10-27T07:09:33Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://doi.org/10.1097/MD.0000000000034928 | - |
dc.identifier.uri | https://hdl.handle.net/11499/52870 | - |
dc.description.abstract | Computed tomography (CT) and positron emission tomography (PET) are the most commonly used methods for diagnosis and staging in both malignant and benign diseases of the lung parenchyma and mediastinum. Endobronchial ultrasonography (EBUS) guided transbronchial needle aspiration biopsy (TBNA) has become widespread in recent years because it allows minimally invasive tissue sampling. PET-CT has high sensitivity in the diagnosis of malignancy but has low specificity. The false positive rate is high with the SUVmax 2.5 cutoff value, which is widely used in studies about malignancy. In our study, we evaluated lymph nodes with high F18-fluorodeoxyglucose (FDG) uptake on PET/CT and sampled by EBUS-TBNA. We aimed to calculate the new SUVmax cutoff values in the differentiation of malignancy. Our study included 103 patients who were examined for any reason and who underwent biopsy with EBUS-TBNA due to mediastinal or hilar lymph node enlargement on PET-CT. The relationship between PET-CT findings and EBUS findings, EBUS-TBNA results was evaluated. Biopsies were taken from 140 lymph nodes in 103 patients included in our study, and 39 (27.8%) were diagnosed as malignant. In our study, when the SUVmax cutoff value in PET-CT is taken as 2.54, the sensitivity is 98%, but the specificity remains at the level of 12%. When the SUVmax cutoff value in PET-CT was taken as 4.58, the sensitivity was 92% and the specificity was 49%. When this value was accepted as 5.25, and 6.09 the sensitivity was respectively 90% and 85%, the specificity was respectively 52% and 60%. In evaluations, we conducted in order to determine different SUVmax cutoff values that can be used for higher sensitivity and specificity in malignancy studies, the cutoff values were 4.58, 5.25, and 6.09. It is thought that these cutoff values will be useful both for diagnosing malignancy and for distinguishing benign pathologies. Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. | en_US |
dc.description.sponsorship | 2018KRM009 | en_US |
dc.description.sponsorship | This study was supported by Pamukkale University Scientific Research Projects Coordination Unit through project number 2018KRM009. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott Williams and Wilkins | en_US |
dc.relation.ispartof | Medicine (United States) | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | EBUS | en_US |
dc.subject | PET-CT | en_US |
dc.subject | sensitivity | en_US |
dc.subject | specificity | en_US |
dc.subject | SUVmax | en_US |
dc.subject | diagnostic imaging | en_US |
dc.subject | fine needle aspiration biopsy | en_US |
dc.subject | human | en_US |
dc.subject | lung | en_US |
dc.subject | lymph node | en_US |
dc.subject | mediastinum | en_US |
dc.subject | neoplasm | en_US |
dc.subject | positron emission tomography-computed tomography | en_US |
dc.subject | Biopsy, Fine-Needle | en_US |
dc.subject | Humans | en_US |
dc.subject | Lung | en_US |
dc.subject | Lymph Nodes | en_US |
dc.subject | Mediastinum | en_US |
dc.subject | Neoplasms | en_US |
dc.subject | Positron Emission Tomography Computed Tomography | en_US |
dc.title | Evaluation of hypermetabolic mediastinal-hilar lymph nodes determined by PET/CT with EBUS-TBNA and calculation of SUVmax cutoff values in differentiation of malignancy | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 102 | en_US |
dc.identifier.issue | 35 | en_US |
dc.identifier.startpage | E34928 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1097/MD.0000000000034928 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorscopusid | 56158762100 | - |
dc.authorscopusid | 58559498200 | - |
dc.authorscopusid | 57219858020 | - |
dc.authorscopusid | 57200699270 | - |
dc.authorscopusid | 22333756200 | - |
dc.authorscopusid | 56667569600 | - |
dc.authorscopusid | 55883345200 | - |
dc.identifier.pmid | 37657039 | en_US |
dc.identifier.scopus | 2-s2.0-85169525606 | en_US |
dc.identifier.wos | WOS:001159475800011 | en_US |
dc.institutionauthor | … | - |
dc.identifier.scopusquality | Q3 | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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medi-102-e34928.pdf | 457.39 kB | Adobe PDF | View/Open |
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