Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/5297
Title: | Comparative study of 0.1% olopatadine hydrochloride and 0.5% ketorolac tromethamine in the treatment of seasonal allergic conjunctivitis | Authors: | Yaylalı, Volkan Demirlenk, İbrahim Tatlıpınar, Sinan Özbay, Davut Esme, Arif Yıldırım, Cem Özden, Serap |
Keywords: | Ketorolac Ocular allergy Olopatadine Seasonal allergic conjunctivitis antazoline antihistaminic agent cromoglycate disodium histamine H1 receptor antagonist ketorolac trometamol naphazoline nonsteroid antiinflammatory agent olopatadine placebo tears naturale tears naturale ii vasoconstrictor agent adult allergic conjunctivitis article clinical article clinical trial conjunctival hyperemia controlled clinical trial controlled study drug activity drug effect drug efficacy drug mechanism female human lacrimation male mucus secretion ocular pruritus parallel design priority journal randomized controlled trial scoring system statistical significance symptomatology visual system parameters Adolescent Adult Anti-Inflammatory Agents, Non-Steroidal Conjunctiva Conjunctivitis, Allergic Dibenzoxepins Female Histamine H1 Antagonists Humans Hyperemia Ketorolac Tromethamine Male Ophthalmic Solutions Therapeutic Equivalency |
Abstract: | Purpose: To compare the therapeutic effects of two ophthalmic solutions (0.1% olopatadine hydrochloride and 0.5% ketorolac tromethamine) with different pharmacological mechanisms on the clinical signs and Symptoms of seasonal allergic conjunctivitis (SAC). Methods: Forty patients with the signs and symptoms of SAC (i.e. hyperaemia, itching, mucus discharge, tearing) were included in this placebo-controlled, randomized, parallel group, single centre study. In group 1 (20 patients) one eye of each patient was treated with olopatadine and the other with placebo. In group 2 (20 patients) one eye of each patient was treated with ketorolac solution and the other with placebo. The principal signs and symptoms of SAC (hyperaemia and itching) were evaluated at 30 mins and at 2, 7 and 15 days. Results: In group 1, both parameters improved significantly in eyes treated with olopatadine compared with those receiving placebo at all control examinations (all p<0.05). Similarly, eyes treated with ketorolac showed significant reductions in signs and symptoms compared with those receiving placebo (all p<0.05). When the clinical parameters of eyes treated with olopatadine were compared with those treated with ketorolac, the mean score of hyperaemia was found to be lower in the olopatadine group, but the difference was not statistically significant (all p>0.05). However, the itching score was significantly lower in the olopatadine group from the second day through to the end of the study (p<0.05). Conclusions: Both olopatadine and ketorolac ophthalmic solutions were found to be effective in alleviating the clinical signs and symptoms of SAC compared to placebo. However, olopatadine reduces ocular itching significantly more than ketorolac. | URI: | https://hdl.handle.net/11499/5297 https://doi.org/10.1034/j.1600-0420.2003.00079.x |
ISSN: | 1395-3907 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
j.1600-0420.2003.00079.x.pdf | 103.6 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
54
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
43
checked on Dec 5, 2024
Page view(s)
86
checked on Aug 24, 2024
Download(s)
34
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.