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https://hdl.handle.net/11499/5299
Title: | The addition of droperidol or clonidine to epidural tramadol shortens onset time and increases duration of postoperative analgesia | Authors: | Gürses, Ercan Sungurtekin, Hülya Tomatır, Erkan Balcı, Canan Gönüllü, Mustafa |
Keywords: | alfentanil antiemetic agent calcitonin cisatracurium clonidine droperidol ephedrine fentanyl ketamine metoclopramide midazolam morphine neostigmine nitrous oxide plus oxygen noradrenalin uptake inhibitor pethidine propofol Ringer lactate solution serotonin uptake inhibitor somatostatin sufentanil tramadol abdominal surgery adult aged anxiety disorder article bradycardia breathing rate clinical trial controlled clinical trial controlled study drug effect epidural catheter extrapyramidal symptom female heart arrhythmia heart rate human hypotension long QT syndrome lumbar spine major clinical study male monotherapy motor dysfunction nausea and vomiting neurotoxicity oxygen saturation pain assessment panic postoperative analgesia postoperative pain priority journal randomized controlled trial sedation side effect time visual analog scale |
Publisher: | Canadian Anaesthetists' Society | Abstract: | Purpose: To compare tramadol alone and the combinations of either tramadol-clonidine or tramadol-droperidol with regard to analgesic and adverse effects. Methods: After Ethic's Committee approval and patient informed consent were obtained, epidural catheters were inserted preoperatively at the L3-4 interspace in 90 ASA physical status I-II adult patients undergoing lower abdominal surgery. Anesthesia was standardized. Patients were randomly assigned to one of three groups. Group I (T) patients received tramadol 75 mg, Group II (TD) patients received tramadol 75 mg plus droperidol 2.5 mg, and Group III (TC) patients received tramadol 75 mg plus clonidine 150 µg in a total volume of 10 mL administered as a single epidural injection in the postanesthesia care unit. The onset time of analgesia and duration of analgesia, visual analogue pain scores, sedation, nausea scores, vital signs and side effects were recorded. Results: Duration of analgesia was similar in both the TD and TC groups, and significantly longer than in the T group (P < 0.001). Group TC patients displayed a significant increase in sedation scores and decrease in blood pressure and heart rate when compared with other groups (P < 0.001). No adverse effects were observed in Group TD, while nausea scores were high in both the T and TC groups (P < 0.001). Pain score, respiration rate, and SpO2 values were similar in all study groups. Conclusion: We conclude that epidural tramadol in combination with droperidol or clonidine prolongs the duration of analgesia; however, droperidol appears to be a better alternative when adverse effects and antiemetic properties are taken into consideration. | URI: | https://hdl.handle.net/11499/5299 https://doi.org/10.1007/BF03017847 |
ISSN: | 0832-610X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Gürses2003_Article_TheAdditionOfDroperidolOrCloni.pdf | 127.59 kB | Adobe PDF | View/Open |
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