Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5299
Title: The addition of droperidol or clonidine to epidural tramadol shortens onset time and increases duration of postoperative analgesia
Authors: Gürses, Ercan
Sungurtekin, Hülya
Tomatır, Erkan
Balcı, Canan
Gönüllü, Mustafa
Keywords: alfentanil
antiemetic agent
calcitonin
cisatracurium
clonidine
droperidol
ephedrine
fentanyl
ketamine
metoclopramide
midazolam
morphine
neostigmine
nitrous oxide plus oxygen
noradrenalin uptake inhibitor
pethidine
propofol
Ringer lactate solution
serotonin uptake inhibitor
somatostatin
sufentanil
tramadol
abdominal surgery
adult
aged
anxiety disorder
article
bradycardia
breathing rate
clinical trial
controlled clinical trial
controlled study
drug effect
epidural catheter
extrapyramidal symptom
female
heart arrhythmia
heart rate
human
hypotension
long QT syndrome
lumbar spine
major clinical study
male
monotherapy
motor dysfunction
nausea and vomiting
neurotoxicity
oxygen saturation
pain assessment
panic
postoperative analgesia
postoperative pain
priority journal
randomized controlled trial
sedation
side effect
time
visual analog scale
Publisher: Canadian Anaesthetists' Society
Abstract: Purpose: To compare tramadol alone and the combinations of either tramadol-clonidine or tramadol-droperidol with regard to analgesic and adverse effects. Methods: After Ethic's Committee approval and patient informed consent were obtained, epidural catheters were inserted preoperatively at the L3-4 interspace in 90 ASA physical status I-II adult patients undergoing lower abdominal surgery. Anesthesia was standardized. Patients were randomly assigned to one of three groups. Group I (T) patients received tramadol 75 mg, Group II (TD) patients received tramadol 75 mg plus droperidol 2.5 mg, and Group III (TC) patients received tramadol 75 mg plus clonidine 150 µg in a total volume of 10 mL administered as a single epidural injection in the postanesthesia care unit. The onset time of analgesia and duration of analgesia, visual analogue pain scores, sedation, nausea scores, vital signs and side effects were recorded. Results: Duration of analgesia was similar in both the TD and TC groups, and significantly longer than in the T group (P < 0.001). Group TC patients displayed a significant increase in sedation scores and decrease in blood pressure and heart rate when compared with other groups (P < 0.001). No adverse effects were observed in Group TD, while nausea scores were high in both the T and TC groups (P < 0.001). Pain score, respiration rate, and SpO2 values were similar in all study groups. Conclusion: We conclude that epidural tramadol in combination with droperidol or clonidine prolongs the duration of analgesia; however, droperidol appears to be a better alternative when adverse effects and antiemetic properties are taken into consideration.
URI: https://hdl.handle.net/11499/5299
https://doi.org/10.1007/BF03017847
ISSN: 0832-610X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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