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https://hdl.handle.net/11499/5309
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Özden, Serap | - |
dc.contributor.author | Tatlıpınar, Sinan | - |
dc.contributor.author | Biçer, N. | - |
dc.contributor.author | Yaylalı, Volkan | - |
dc.contributor.author | Yıldırım, Cem | - |
dc.contributor.author | Özbay, Davut | - |
dc.contributor.author | Güner, Gül | - |
dc.date.accessioned | 2019-08-16T11:44:32Z | |
dc.date.available | 2019-08-16T11:44:32Z | |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0008-4182 | - |
dc.identifier.uri | https://hdl.handle.net/11499/5309 | - |
dc.identifier.uri | https://doi.org/10.1016/S0008-4182(03)80051-0 | - |
dc.description.abstract | Purpose: To compare the basal serum levels of nitric oxide (NO) in patients with type 2 diabetes mellitus and different stages of diabetic retinopathy (DR) with the levels in nondiabetic control subjects. Methods: The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR. Eleven non-diabetic subjects made up the control group (group D). The NO concentration was determined indirectly by measuring the serum level of nitrite (NO2 -) plus nitrate (NO3 -) (NO x = NO2 - plus NO3 -) using a spectrophotometric method based on the Griess reaction. Results: The patients with type 2 diabetes had significantly higher levels of serum NO x than the nondiabetic controls (p = 0.0001). In addition, the levels in the patients with proliferative DR were significantly higher (p = 0.002) than the levels in the patients with nonproliferative or no DR. Conclusion: Our study demonstrated both elevated levels of serum NOx in diabetic patients as compared with nondiabetic controls and a relationship between NOx and DR severity. Hence, abnormal NO metabolism may have a role in the pathogenesis of DR. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier B.V. | en_US |
dc.relation.ispartof | Canadian Journal of Ophthalmology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Diabetic retinopathy | en_US |
dc.subject | Nitric oxide | en_US |
dc.subject | nitric oxide | en_US |
dc.subject | article | en_US |
dc.subject | blood level | en_US |
dc.subject | clinical article | en_US |
dc.subject | controlled study | en_US |
dc.subject | correlation analysis | en_US |
dc.subject | diabetic retinopathy | en_US |
dc.subject | disease activity | en_US |
dc.subject | disease severity | en_US |
dc.subject | human | en_US |
dc.subject | non insulin dependent diabetes mellitus | en_US |
dc.subject | pathogenesis | en_US |
dc.subject | spectrophotometry | en_US |
dc.title | Basal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathy | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 38 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 393 | |
dc.identifier.startpage | 393 | en_US |
dc.identifier.endpage | 396 | en_US |
dc.identifier.doi | 10.1016/S0008-4182(03)80051-0 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 12956281 | en_US |
dc.identifier.scopus | 2-s2.0-0142058890 | en_US |
dc.identifier.wos | WOS:000184847100009 | en_US |
dc.identifier.scopusquality | Q1 | - |
dc.owner | Pamukkale_University | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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