Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5309
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dc.contributor.authorÖzden, Serap-
dc.contributor.authorTatlıpınar, Sinan-
dc.contributor.authorBiçer, N.-
dc.contributor.authorYaylalı, Volkan-
dc.contributor.authorYıldırım, Cem-
dc.contributor.authorÖzbay, Davut-
dc.contributor.authorGüner, Gül-
dc.date.accessioned2019-08-16T11:44:32Z
dc.date.available2019-08-16T11:44:32Z
dc.date.issued2003-
dc.identifier.issn0008-4182-
dc.identifier.urihttps://hdl.handle.net/11499/5309-
dc.identifier.urihttps://doi.org/10.1016/S0008-4182(03)80051-0-
dc.description.abstractPurpose: To compare the basal serum levels of nitric oxide (NO) in patients with type 2 diabetes mellitus and different stages of diabetic retinopathy (DR) with the levels in nondiabetic control subjects. Methods: The 39 patients with type 2 diabetes included in this study were divided by stage of DR into 3 groups: group A, those without DR; group B, those with background/preproliferative DR; and group C, those with proliferative DR. Eleven non-diabetic subjects made up the control group (group D). The NO concentration was determined indirectly by measuring the serum level of nitrite (NO2 -) plus nitrate (NO3 -) (NO x = NO2 - plus NO3 -) using a spectrophotometric method based on the Griess reaction. Results: The patients with type 2 diabetes had significantly higher levels of serum NO x than the nondiabetic controls (p = 0.0001). In addition, the levels in the patients with proliferative DR were significantly higher (p = 0.002) than the levels in the patients with nonproliferative or no DR. Conclusion: Our study demonstrated both elevated levels of serum NOx in diabetic patients as compared with nondiabetic controls and a relationship between NOx and DR severity. Hence, abnormal NO metabolism may have a role in the pathogenesis of DR.en_US
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofCanadian Journal of Ophthalmologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectDiabetic retinopathyen_US
dc.subjectNitric oxideen_US
dc.subjectnitric oxideen_US
dc.subjectarticleen_US
dc.subjectblood levelen_US
dc.subjectclinical articleen_US
dc.subjectcontrolled studyen_US
dc.subjectcorrelation analysisen_US
dc.subjectdiabetic retinopathyen_US
dc.subjectdisease activityen_US
dc.subjectdisease severityen_US
dc.subjecthumanen_US
dc.subjectnon insulin dependent diabetes mellitusen_US
dc.subjectpathogenesisen_US
dc.subjectspectrophotometryen_US
dc.titleBasal serum nitric oxide levels in patients with type 2 diabetes mellitus and different stages of retinopathyen_US
dc.typeArticleen_US
dc.identifier.volume38en_US
dc.identifier.issue5en_US
dc.identifier.startpage393
dc.identifier.startpage393en_US
dc.identifier.endpage396en_US
dc.identifier.doi10.1016/S0008-4182(03)80051-0-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid12956281en_US
dc.identifier.scopus2-s2.0-0142058890en_US
dc.identifier.wosWOS:000184847100009en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale_University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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