Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5315
Title: Neuroendocrine differentiated carcinomas of the breast: A distinct entity
Authors: Zekioglu, O.
Erhan, Y.
Çiriş, M.
Bayramoğlu, Hatice
Keywords: Breast
Carcinoma
Neuroendocrine
alcian blue
avidin
biotin
chromogranin
eosin
estrogen receptor
formaldehyde
hematoxylin
Ki 67 antigen
monoclonal antibody
mucin
neuron specific enolase
oncoprotein
progesterone receptor
protein p53
synaptophysin
adult
aged
article
breast carcinoma
cancer classification
clinical article
clinical feature
controlled study
female
histopathology
human
human tissue
immunohistochemistry
mastectomy
Merkel cell tumor
neuroendocrine tumor
papilloma
partial mastectomy
priority journal
signet ring carcinoma
solid tumor
tissue differentiation
tissue section
tumor cell
tumor classification
tumor growth
tumor volume
Publisher: Churchill Livingstone
Abstract: Some primary carcinomas of the breast have been classified as neuroendocrine. In this paper we report on 12 cases of neuroendocrine carcinoma of the breast displaying common and uncommon histological features. Materials and methods: All patients were aged from 43 to 79 (median 66.5) years. The tumors were unilateral and ranged from 0.8 to 7 cm (median 2.35 cm) in diameter. Four tumors were classified as solid cohesive, two as solid papillary, one as Merkel cell-like, two as cellular mucinous, two as cellular mucinous with micropapillary features and one as cellular mucinous with prominent signet ring cells. The tissues were fixed in formalin and routinely processed. All materials were stained with PAS, Alcian blue and also hematoxylin and eosin. Immunohistochemical examination was carried out by the avidin-biotin method using the following antibodies: estrogen receptor protein, progesterone receptor protein, p53, cerbB-2, Ki67, neuron-specific enolase, chromogranin, and synaptophysin. Results: In all cases the tumor cells were stained positively with NSE. Synaptophysin and chromogranin positivity was detected in 11 and five cases, respectively. The prominent histological features were: extensive intraductal growth, pseudorosettes and palisades, low-grade cytologic atypia, plasmacytoid appearance of the tumor cells, and intracellular and extracellular mucin. Conclusion: Neuroendocrine-differentiated carcinoma of the breast is a rare and distinct category with different histological subtypes. © 2003 Elsevier Science Ltd. All rights reserved.
URI: https://hdl.handle.net/11499/5315
https://doi.org/10.1016/S0960-9776(03)00059-6
ISSN: 0960-9776
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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