Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5322
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dc.contributor.authorBolaman, Z.-
dc.contributor.authorKöseo?lu, M.H.-
dc.contributor.authorDemir, S.-
dc.contributor.authorKadiköylü, G.-
dc.contributor.authorBarutca, S.-
dc.contributor.authorAtalay, H.-
dc.contributor.authorAslan, D.-
dc.date.accessioned2019-08-16T11:44:44Z-
dc.date.available2019-08-16T11:44:44Z-
dc.date.issued2003-
dc.identifier.issn1300-7777-
dc.identifier.urihttps://hdl.handle.net/11499/5322-
dc.description.abstractCisplatin (CDDP) is one of the most commonly used antineoplastic agents in current clinical practice. The major toxicities of CDDP are nonhaematological as nephrotoxicity and ototoxicity. Free oxygen radicals are known to play major role in CDDP-induced acute renal failure in rats. ?-Tocopherol is one of the well-known antioxidant agents. This study was designed to investigate the role of ?-tocopherol pretreatment against CDDP-induced lipid peroxidation in rat kidney. Male Wistar rats were divided into three groups and treated as follows: control (saline intraperitoneally), CDDP (10 mg/kg, intraperitoneally), ?-tocopherol (200 mg/kg, plus CDDP, intraperitoneally). Rats were sacrificed on third day of the treatment, and kidney tissues were obtained and analyzed. CDDP-treated rats showed high malondialdehyde (MDA) levels (p< 0.05). In the CDDP plus ?-tocopherol group, renal MDA levels were not significantly different from the controls. These data suggest that ?-tocopherol may be used to prevent CDDP-induced lipid peroxidation.en_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Haematologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject?-Tocopherolen_US
dc.subjectCisplatinen_US
dc.subjectMalondialdehydeen_US
dc.subjectalpha tocopherolen_US
dc.subjectcisplatinen_US
dc.subjectcisplatinum onkoen_US
dc.subjectlipiden_US
dc.subjectmalonaldehydeen_US
dc.subjectsodium chlorideen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectcalculationen_US
dc.subjectcanceren_US
dc.subjectcontrolled studyen_US
dc.subjectdiet restrictionen_US
dc.subjectdisease associationen_US
dc.subjectdrug antagonismen_US
dc.subjectdrug effecten_US
dc.subjectdrug induced diseaseen_US
dc.subjectkidneyen_US
dc.subjectlipid peroxidationen_US
dc.subjectmaleen_US
dc.subjectnephrotoxicityen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjecturine levelen_US
dc.titleEffect of ?-tocopherol on lipid peroxidation caused by cisplatin in rat kidneyen_US
dc.typeArticleen_US
dc.identifier.volume20en_US
dc.identifier.issue1en_US
dc.identifier.startpage35
dc.identifier.startpage35en_US
dc.identifier.endpage38en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-0037226107en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale_University-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
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