Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5365
Title: Modulation of the negative inotropic effect of haloperidol by drugs with positive inotropic effects in isolated rabbit heart
Authors: Hatip-Al-Khatib, Izzettin
Bolukbaşi-Hatip, F.
Keywords: Calcium
Haloperidol
Isolated heart
Negative inotropism
1,4 dihydro 2,6 dimethyl 5 nitro 4 [2 (trifluoromethyl)phenyl] 3 pyridinecarboxylic acid methyl ester
calcium ion
digoxin
dobutamine
dopamine
haloperidol
noradrenalin
calcium
calcium channel stimulating agent
cardiotonic agent
neuroleptic agent
animal tissue
apparatus
article
calcium transport
concentration response
controlled study
drug effect
heart left ventricle pressure
heart muscle cell
heart muscle contractility
inotropism
isolated heart
male
nonhuman
priority journal
rabbit
analysis of variance
animal
chemical phenomena
dose response
heart contraction
heart left ventricle function
heart ventricle pressure
in vitro study
Analysis of Variance
Animal
Antipsychotic Agents, Butyrophenone
Bay-K-8644
Calcium Channel Agonists
Cardiotonic Agents
Depression, Chemical
Digoxin
Dobutamine
Dopamine
Dose-Response Relationship, Drug
In Vitro
Male
Myocardial Contraction
Norepinephrine
Rabbits
Ventricular Function, Left
Ventricular Pressure
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Animals
Antipsychotic Agents
Abstract: Haloperidol is a typical antipsychotic drug with inhibitory effects on dopamine and calcium homeostasis. In this study, the effect of haloperidol on the inotropism of rabbits' isolated heart was investigated by measuring the isovolumetric left ventricular pressure using a balloon in a modified Langendorff perfusion apparatus. Haloperidol at 0.01-0.3 µmol/l induced a negative inotropic effect (Emax = 77.95 ± 0.19; EC50 = 0.043 ± 0.002 µmol/l). The effect of haloperidol was decreased by Ca2+ (Emax = 42.93 ± 3.22; EC50 = 0.37 ± 0.07 µmol/l; pD'2 = 7.01 ± 0.16), Bay K 8644 (Emax = 30.75 ± 1.33; EC50 = 10.43 ± 1.5 µmol/l, pD'2 = 7.13 ± 0.12), and digoxin (Emax = 42.03 ± 3.72, EC50 = 0.32 ± 0.05 µmol/l, pD'2 = 6.81 ± 0.14). The effect of haloperidol was also reduced by norepinephrine (Emax = 37.16 ± 1.84; EC50 = 1.73 ± 0.24 µmol/l, pD'2 = 6.97 ± 0.08) and dopamine (Emax = 35.68 ± 2.78; EC50 = 0.69 ± 0.01 µmol/l, pD'2 = 7.48 ± 0.15). However, the effect of haloperidol was nonsignificantly reduced by dobutamine (Emax = 58.89 ± 5.18; EC50 = 0.15 ± 0.06 µmol/l, pD'2 = 5.88 ± 0.47). These results show that the drugs that increase the influx of Ca2+ into the cardiomyocyte decrease the negative inotropic effect of haloperidol, suggesting that the effect of haloperidol could be mediated via mechanisms involving actions on Ca2+ entry into the cardiomyocyte. Haloperidol should be used carefully when prescribed for patients with cardiovascular disorders. Copyright © 2002 S. Karger AG, Basel.
URI: https://hdl.handle.net/11499/5365
https://doi.org/10.1159/000063249
ISSN: 0031-7012
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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