Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5383
Title: Low dose sultamicillin in acute sinusitis
Authors: Topuz, Bülent
Katircio?lu, O.
Bayramo?lu, I.
Ardiç, F.N.
Erbudak, H.
Keywords: Acute sinusitis
Amoxicillin
Sultamicillin
amoxicillin
sultamicillin
acute disease
adolescent
adult
antibiotic therapy
article
clinical feature
clinical trial
controlled clinical trial
controlled study
disease severity
drug efficacy
female
gastrointestinal symptom
human
major clinical study
male
sinusitis
treatment failure
treatment outcome
Acute Disease
Adolescent
Adult
Ampicillin
Anti-Bacterial Agents
Female
Humans
Male
Middle Aged
Single-Blind Method
Sinusitis
Sulbactam
Abstract: Objectives: to study the effectiveness of low dose sultamicillin in the treatment of acute sinusitis. Methods: a total of 108 patients, between 16-56 years of age (mean 32.8), suffering from acute sinusitis took part in the trial. Patients received orally 2×375 mg sultamicillin, and compared with patients receiving 3×500 mg amoxicillin. The first control was made between the 5th and 7th days. A patient was considered clinically cured when all pretreatment signs and symptoms of infection were eliminated. Clinical improvement was defined as the partial disappearance of pretreatment signs and symptoms. In either result, study drugs were reconstituted for additional 5 days. Failure was defined as no change or worsening of signs and symptoms; and study drug was changed. The second control was made between 10-12th days, and the third was four weeks later. Results: The clinical success (improvement + cure) rate was (17+11)/42 (66.6%) and (28+21)/66 (74.2%) for amoxicillin and sultamicillin respectively, at first control. All improved patients were cured at the second control. No significant side-effects were noted in either amoxicillin or sultamicillin treated patients. All side effects were gastrointestinal, 11.9% and 3.0% in the same order. Conclusions: Low dose sultamicillin was comparable to amoxicillin; sultamicillin has fewer side effects than amoxicillin (p>O.05).
URI: https://hdl.handle.net/11499/5383
ISSN: 1124-9390
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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