Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/5415
Title: | Effects of methimazole pretreatment on cerulein induced acute pancreatitis in rats | Authors: | Yönetçi, Nadir. Oruç, N. Özütemiz, A.Ö Kumanlioglu, K. Yüce, G. Batur, Y. |
Keywords: | Acute pancreatitis Cerulein Methimazole Thyroid hormones amylase antithyroid agent ceruletide liothyronine thiamazole thyroid hormone acute pancreatitis amylase blood level animal experiment animal model article controlled study disease severity drug effect enzyme activity gastrointestinal tract histopathology liothyronine blood level male nonhuman rat thyroid gland thyroxine blood level acute disease animal chemically induced disorder disease model drug antagonism hypothyroidism metabolism pancreatitis Wistar rat Animalia Acute Disease Amylases Animals Caerulein Disease Models, Animal Hypothyroidism Male Pancreatitis Rats Rats, Wistar Thyroid Hormones |
Publisher: | Elsevier GmbH | Abstract: | Background: Many interrelationships exist between the thyroid gland and the gastrointestinal tract. Several past and recent studies have shown that the thyroid gland profoundly influences the structure and function of the exocrine pancreas in the rat. In the present study we investigated the effect of methimazole (METZ), an antithyroid drug, on cerulein induced acute pancreatitis (AP) in rats. Methods: Rats were divided into 3 groups (10-12 weeks age, 200-250 g weight, n: 10). Group B was made hypothyroid with methimazole 5 mg/kg daily for 10 days and the others were untreated euthyroid groups. After 10 days, acute pancreatitis was induced with four doses of 20 pg/kg body weight of cerulein administered s.c at hourly intervals in group A and B while the control group C was given 4 doses of 1 ml saline. Pancreas wet weight (mg), plasma amylase activity (IU/1) and pancreatic histology were used as endpoints to quantify the severity of the AP. Results: Plasma tri-iodothyronine (T3) (ng/d1) and thyroxine (T4) (µg/d1) levels were significantly reduced after METZ treatment for 10 days (p < 0.01). METZ pretreatment reduced significantly the cerulein induced increase in pancreatic weight (1205 ± 12 mg in METZ treated AP group versus 1617 ± 14 mg in AP group, p < 0.05) and the rise in amylase activity (7078 ± 816 IU/1 in METZ treated AP group versus 8611 ± 830 IU/1 in AP group p < 0.05). Conclusion: METZ reduces the severity of cerulein induced AP in rats. This effect might be through its antithyroid property. | URI: | https://hdl.handle.net/11499/5415 https://doi.org/10.1078/0940-2993-00248 |
ISSN: | 0940-2993 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
7
checked on Sep 30, 2024
WEB OF SCIENCETM
Citations
7
checked on Sep 30, 2024
Page view(s)
34
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.