Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5415
Title: Effects of methimazole pretreatment on cerulein induced acute pancreatitis in rats
Authors: Yönetçi, Nadir.
Oruç, N.
Özütemiz, A.Ö
Kumanlioglu, K.
Yüce, G.
Batur, Y.
Keywords: Acute pancreatitis
Cerulein
Methimazole
Thyroid hormones
amylase
antithyroid agent
ceruletide
liothyronine
thiamazole
thyroid hormone
acute pancreatitis
amylase blood level
animal experiment
animal model
article
controlled study
disease severity
drug effect
enzyme activity
gastrointestinal tract
histopathology
liothyronine blood level
male
nonhuman
rat
thyroid gland
thyroxine blood level
acute disease
animal
chemically induced disorder
disease model
drug antagonism
hypothyroidism
metabolism
pancreatitis
Wistar rat
Animalia
Acute Disease
Amylases
Animals
Caerulein
Disease Models, Animal
Hypothyroidism
Male
Pancreatitis
Rats
Rats, Wistar
Thyroid Hormones
Publisher: Elsevier GmbH
Abstract: Background: Many interrelationships exist between the thyroid gland and the gastrointestinal tract. Several past and recent studies have shown that the thyroid gland profoundly influences the structure and function of the exocrine pancreas in the rat. In the present study we investigated the effect of methimazole (METZ), an antithyroid drug, on cerulein induced acute pancreatitis (AP) in rats. Methods: Rats were divided into 3 groups (10-12 weeks age, 200-250 g weight, n: 10). Group B was made hypothyroid with methimazole 5 mg/kg daily for 10 days and the others were untreated euthyroid groups. After 10 days, acute pancreatitis was induced with four doses of 20 pg/kg body weight of cerulein administered s.c at hourly intervals in group A and B while the control group C was given 4 doses of 1 ml saline. Pancreas wet weight (mg), plasma amylase activity (IU/1) and pancreatic histology were used as endpoints to quantify the severity of the AP. Results: Plasma tri-iodothyronine (T3) (ng/d1) and thyroxine (T4) (µg/d1) levels were significantly reduced after METZ treatment for 10 days (p < 0.01). METZ pretreatment reduced significantly the cerulein induced increase in pancreatic weight (1205 ± 12 mg in METZ treated AP group versus 1617 ± 14 mg in AP group, p < 0.05) and the rise in amylase activity (7078 ± 816 IU/1 in METZ treated AP group versus 8611 ± 830 IU/1 in AP group p < 0.05). Conclusion: METZ reduces the severity of cerulein induced AP in rats. This effect might be through its antithyroid property.
URI: https://hdl.handle.net/11499/5415
https://doi.org/10.1078/0940-2993-00248
ISSN: 0940-2993
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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