Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5430
Title: Effects of L-arginine on the brain ischaemia-reperfusion damage in rats: An investigation by somatosensory evoked potentials and histopathology
Authors: Kurt, Tülay
Oguzhanoglu, Atilla
Ortaç, R.
Turman, B.
Adıgüzel, Esat
Keywords: Cerebral ischaemia-reperfusion damage
L-arginine
Nitric oxide
arginine
nitric oxide
animal experiment
animal model
animal tissue
article
brain cell
brain injury
brain ischemia
cell damage
concentration response
controlled study
drug effect
evoked somatosensory response
female
histopathology
male
neuropathology
neuroprotection
nonhuman
quantitative analysis
reperfusion injury
Abstract: We investigated whether administration of L-arginine reduces the ischaemia-reperfusion damage in the rat brain. The effects of L-arginine were evaluated by means of somatosensory evoked potential (SEP) measurements and quantitative histopathological investigations. There was no significant difference between groups based on SEP data. The results obtained from quantitative histopathological investigations indicate that the nitric oxide (NO) precursor L-arginine does not appear to have a protective effect on the brain ischaemia-reperfusion damage. Furthermore, histopathological evaluation revealed a higher number of damaged cells in the L-arginine treated rats than in control group. The results of the present study suggest that high concentrations of L-arginine present in later stages of reperfusion might have harmful effects on reperfusion damage in the brain.
URI: https://hdl.handle.net/11499/5430
https://doi.org/10.1002/nrc.10050
ISSN: 0893-6609
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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