Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5443
Title: Cardiovascular safety of cocaine anaesthesia in the presence of adrenaline during septal surgery
Authors: Kara, Cüneyt Orhan
Kaftan, Asuman
Atalay, Habip
Pınar, Hilmi Şafak
Ögmen, Gülsen
Keywords: Anaesthesia
Cardiovascular side effects
Cocaine
adrenalin
cocaine
lidocaine
adult
analysis of variance
article
cardiotoxicity
cardiovascular system
drug absorption
drug safety
electrocardiogram
female
heart bundle branch block
human
hypertension
hypotension
local anesthesia
major clinical study
male
nose surgery
patient selection
priority journal
sinus tachycardia
tachycardia
thorax pain
topical anesthesia
vasoconstriction
Adult
Anesthesia, Local
Anesthetics, Combined
Blood Pressure
Cardiovascular System
Electrocardiography
Epinephrine
Female
Heart Rate
Humans
Male
Middle Aged
Nasal Septum
Otorhinolaryngologic Surgical Procedures
Solutions
Abstract: Objective: The purpose of this study was to investigate the possible cardiovascular side effects of 4% cocaine solution in the presence of adrenaline during septal surgery. Method: Sixty adult patients undergoing elective septal surgery with local anaesthesia were included in the study. Noses were packed with 5-mL 4% cocaine (200-mg) solution on cotton pledgets, which were left in the nose for 15 minutes. Then, 10 mL of local anaesthetic (lidocaine 2% and adrenaline 1:100,000) were infiltrated in septal mucosa, and 15 minutes later, the surgical procedure was initiated. At the beginning of the operation, intervals from 12-lead surface electrocardiograms and vital signs including blood pressures and heart rate were recorded as a baseline. All measurements were repeated just before local anaesthetic infiltration, just before the beginning of the surgical procedure, and, finally, at the end of the operation. All four measurements and electrocardiographic tracings were examined. Systolic and diastolic blood pressures and QT parameters, RR intervals, and heart rates obtained from electrocardiogram were compared statistically with repeated-measures analysis of variance. Results: No statistically significant difference was found among all four staged measurements. None of the patients developed tachycardia, hypertension, hypotension, or any chest pain. In electrocardiogram tracings, no sinus tachycardia depression, elevation, or bundle branch block was noted. Conclusion: This study shows that concomitant use of cocaine and adrenaline in the proper concentration and volume and in a carefully screened patient group was safe for the cardiovascular system.
URI: https://hdl.handle.net/11499/5443
https://doi.org/10.2310/7070.2001.20197
ISSN: 0381-6605
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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