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https://hdl.handle.net/11499/5444
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DC Field | Value | Language |
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dc.contributor.author | Hatip-Al-Khatib, İzzettin | - |
dc.contributor.author | Bölükbaşı, Funda Fatma | - |
dc.contributor.author | Mishima, K. | - |
dc.contributor.author | Egashira, N. | - |
dc.contributor.author | Iwasaki, K. | - |
dc.contributor.author | Fujiwara, M. | - |
dc.date.accessioned | 2019-08-16T11:47:13Z | - |
dc.date.available | 2019-08-16T11:47:13Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0021-5198 | - |
dc.identifier.uri | https://hdl.handle.net/11499/5444 | - |
dc.identifier.uri | https://doi.org/10.1254/jjp.87.277 | - |
dc.description.abstract | We investigated modification of the MK-801 effect on motor activity and extracellular amines concentration by 6-hydroxydopamine (6-OHDA)-induced lesion of core nucleus accumbens (cACC) of rats. In vivo microdialysis-HPLC showed that the concentrations (fmol/µl) of dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and serotonin were 0.738±0.135, 155.34±41.01 and 0.334±0.024, respectively, in the cACC of intact rats. The DOPAC/DA ratio was 264.24±94.01. Unilateral lesion of the cACC with 6-OHDA (8 µg/µl) substantially reduced DA (-93%) and DOPAC (-97%) in desipramine (30 mg/kg, i.p.)-pretreated rats (6-OHDA+DMI rats) as compared to the 65% reduction rate of both amines in saline-pretreated rats (6-OHDA+saline rats). Moreover, DOPAC was reduced by 72% in 6-OHDA+DMI rats. MK-801 increased DOPAC (426-467%) and DOPAC/DA ratio (180-230%) in intact rats. On the other hand, MK-801 increased DA by 154% and 505% in 6-OHDA+saline and 6-OHDA+DMI rats, respectively. 6-OHDA reduced the effect of MK-801 on DOPAC and DOPAC/DA ratio. In the behevioral studies, MK-801 (0.01 - 0.3 mg/kg, i.p.) increased locomotor activity and rearing of intact rats. Bilateral 6-OHDA+DMI mesion of the cACC caused greater reduction in the effect of MK-801 (0.1 mg/kg) than that of the shell nucleus accumbens. These results suggest that increased extracellular DOPAC concentration (but not DA) and DOPAC/DA ratio in the cACC plays an important role in MK-801-hyperactivity. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Japanese Journal of Pharmacology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Core nucleus accumbens (rat) | en_US |
dc.subject | Microdialysis | en_US |
dc.subject | MK-801 | en_US |
dc.subject | Motor activity | en_US |
dc.subject | 3,4 dihydroxyphenylacetic acid | en_US |
dc.subject | amine | en_US |
dc.subject | desipramine | en_US |
dc.subject | dizocilpine | en_US |
dc.subject | dopamine | en_US |
dc.subject | oxidopamine | en_US |
dc.subject | serotonin | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal tissue | en_US |
dc.subject | article | en_US |
dc.subject | behavior | en_US |
dc.subject | brain injury | en_US |
dc.subject | cell level | en_US |
dc.subject | comparative study | en_US |
dc.subject | concentration (parameters) | en_US |
dc.subject | controlled study | en_US |
dc.subject | dopaminergic system | en_US |
dc.subject | dose response | en_US |
dc.subject | drug effect | en_US |
dc.subject | extracellular space | en_US |
dc.subject | high performance liquid chromatography | en_US |
dc.subject | hyperactivity | en_US |
dc.subject | in vivo study | en_US |
dc.subject | male | en_US |
dc.subject | microdialysis | en_US |
dc.subject | motor activity | en_US |
dc.subject | nonhuman | en_US |
dc.subject | nucleus accumbens | en_US |
dc.subject | rat | en_US |
dc.subject | rearing | en_US |
dc.subject | 3,4-Dihydroxyphenylacetic Acid | en_US |
dc.subject | Animals | en_US |
dc.subject | Chromatography, High Pressure Liquid | en_US |
dc.subject | Dizocilpine Maleate | en_US |
dc.subject | Dopamine | en_US |
dc.subject | Electrochemistry | en_US |
dc.subject | Excitatory Amino Acid Antagonists | en_US |
dc.subject | Extracellular Space | en_US |
dc.subject | Male | en_US |
dc.subject | Motor Activity | en_US |
dc.subject | Nucleus Accumbens | en_US |
dc.subject | Oxidopamine | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Wistar | en_US |
dc.subject | Serotonin | en_US |
dc.subject | Stereotaxic Techniques | en_US |
dc.subject | Sympathectomy, Chemical | en_US |
dc.subject | Sympatholytics | en_US |
dc.title | Role of dopaminergic system in core part of nucleus accumbens in hyperlocomotion and rearing induced by MK-801 in rats: A behavioral and in vivo microdialysis study | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 87 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 277 | - |
dc.identifier.startpage | 277 | en_US |
dc.identifier.endpage | 287 | en_US |
dc.authorid | 0000-0002-9127-6779 | - |
dc.identifier.doi | 10.1254/jjp.87.277 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 11829147 | en_US |
dc.identifier.scopus | 2-s2.0-0035683908 | en_US |
dc.identifier.wos | WOS:000172888100005 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale_University | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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