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https://hdl.handle.net/11499/5447
Title: | Capsaicin effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion | Authors: | Sarıoğlu-Büke, Akile Erdem, S. Gedikoglu, G. Bingol-Kologlu, M. Tanyel, F.C. |
Keywords: | Apoptosis Capsaicin Contralateral testicular damage Spermatic cord torsion blocking agent capsaicin cell nucleus DNA DNA fragment paraffin animal cell animal experiment animal model animal tissue apoptosis article cell count cell protection controlled study data analysis drug efficacy male nerve block nonhuman priority journal randomization rat recording scoring system seminiferous tubule staining surgical technique testis testis cell testis torsion Animals Male Random Allocation Rats Spermatic Cord Torsion Testis |
Abstract: | Objective: To evaluate the effect of afferent nerve blockage by administration of capsaicin on apoptotic changes in the contralateral testis in rats undergoing ipsilateral testicular torsion. Materials and methods: Twenty male albino rats were randomly divided into four groups. In groups 1 and 2, rats underwent a sham operation and testicular torsion, respectively, after the intraperitoneal administration of 0.9% NaCl. Similarly, in groups 3 and 4 the rats underwent a sham operation and testicular torsion, respectively, after an intraperitoneal capsaicin injection. The testes were untwisted 24 h later and the contralateral testes harvested. Apoptosis was assessed in paraffin-embedded sections stained for nuclear DNA fragmentation. Fifteen cells were counted in each seminiferous tubule and the apoptotic cells recorded. A score was calculated for each group and the results compared using the Kruskal-Wallis analysis of variance and Mann Whitney U-tests, with P < 0.05 considered to be significant. Results: The mean apoptotic score of group 2 was significantly higher than that of the other groups. There was no difference between the apoptotic scores of groups 1 and 3, 1 and 4, and 3 and 4. Conclusion: Capsaicin effectively prevented apoptosis in the contralateral testes of rats that had undergone testicular torsion. | URI: | https://hdl.handle.net/11499/5447 https://doi.org/10.1046/j.1464-410X.2001.02372.x |
ISSN: | 1464-4096 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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