Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5447
Title: Capsaicin effectively prevents apoptosis in the contralateral testis after ipsilateral testicular torsion
Authors: Sarıoğlu-Büke, Akile
Erdem, S.
Gedikoglu, G.
Bingol-Kologlu, M.
Tanyel, F.C.
Keywords: Apoptosis
Capsaicin
Contralateral testicular damage
Spermatic cord torsion
blocking agent
capsaicin
cell nucleus DNA
DNA fragment
paraffin
animal cell
animal experiment
animal model
animal tissue
apoptosis
article
cell count
cell protection
controlled study
data analysis
drug efficacy
male
nerve block
nonhuman
priority journal
randomization
rat
recording
scoring system
seminiferous tubule
staining
surgical technique
testis
testis cell
testis torsion
Animals
Male
Random Allocation
Rats
Spermatic Cord Torsion
Testis
Abstract: Objective: To evaluate the effect of afferent nerve blockage by administration of capsaicin on apoptotic changes in the contralateral testis in rats undergoing ipsilateral testicular torsion. Materials and methods: Twenty male albino rats were randomly divided into four groups. In groups 1 and 2, rats underwent a sham operation and testicular torsion, respectively, after the intraperitoneal administration of 0.9% NaCl. Similarly, in groups 3 and 4 the rats underwent a sham operation and testicular torsion, respectively, after an intraperitoneal capsaicin injection. The testes were untwisted 24 h later and the contralateral testes harvested. Apoptosis was assessed in paraffin-embedded sections stained for nuclear DNA fragmentation. Fifteen cells were counted in each seminiferous tubule and the apoptotic cells recorded. A score was calculated for each group and the results compared using the Kruskal-Wallis analysis of variance and Mann Whitney U-tests, with P < 0.05 considered to be significant. Results: The mean apoptotic score of group 2 was significantly higher than that of the other groups. There was no difference between the apoptotic scores of groups 1 and 3, 1 and 4, and 3 and 4. Conclusion: Capsaicin effectively prevented apoptosis in the contralateral testes of rats that had undergone testicular torsion.
URI: https://hdl.handle.net/11499/5447
https://doi.org/10.1046/j.1464-410X.2001.02372.x
ISSN: 1464-4096
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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