Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5464
Title: The effect of trimetazidine on the survival of rat island skin flaps subjected to ischemia-reperfusion injury
Authors: Gökalan Kara, İnci
Kara, Cüneyt Orhan
Özden, Akın
Öçsel, Hakan
Keywords: trimetazidine
animal experiment
animal model
artery occlusion
article
controlled study
drug effect
female
graft survival
inferior epigastric artery
ischemia
nonhuman
priority journal
rat
reperfusion injury
skin island flap
Animals
Antioxidants
Female
Graft Survival
Rats
Rats, Wistar
Reperfusion Injury
Surgical Flaps
Trimetazidine
Vasodilator Agents
Abstract: The effect of trimetazidine (TMZ) on flap ischemia-reperfusion injury was investigated in rat inferior epigastric artery flaps. Twenty-six rats, divided into four experimental groups - Nonischemic group (group 1, N = 5), ischemic control group (group 2, N = 7), preischemic TMZ-treated group (group 3, N = 7), and postischemic TMZ-treated group (group 4, N = 7) - Were used. Rat inferior epigastric artery flaps were rendered ischemic by occluding the feeding femoral artery, and they were reperfused by releasing the clamps after 11 hours in groups 2 through 4. Group 3 rats were given TMZ (3 mg per kilogram, intravenously) diluted in saline before application of the clamp, and group 4 rats were given TMZ before clamp removal. Flap survival was scored on postoperative day 8. All flaps in the nonischemic control group (group 1) survived completely. The ischemic control group (group 2) demonstrated a 6.3 ± 4.3% survival area. In the preischemic TMZ group (group 3) the mean survival area was 76.9 ± 6.1%, and in the postischemic TMZ group (group 4) it was 76.8 ± 5.6%. TMZ-treated flaps showed a significant increase in survival area regardless of the time of administration (p = 0.001, group 3 vs. group 2; p = 0.001, group 4 vs. group 2). This finding suggests that TMZ has a beneficial effect on the prevention or treatment of arterial ischemic flaps.
URI: https://hdl.handle.net/11499/5464
ISSN: 0148-7043
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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