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https://hdl.handle.net/11499/5469
Title: | Effect of trimetazidine on retinal ischemia/reperfusion injury in rats | Authors: | Özden, Serap Kıldacı, Bahriye Muftuoglu, S. Cakar, N. Yıldırım, Cem |
Keywords: | Rat retina Retinal ischemia/reperfusion Trimetazidine trimetazidine animal experiment article cell protection controlled study histopathology nonhuman rat reperfusion injury retina bipolar ganglion cell retina injury retina ischemia Animals Antioxidants Cytoprotection Models, Animal Rats Rats, Wistar Reperfusion Injury Retina |
Abstract: | Purpose: To investigate the effect of trimetazidine (TMZ), an antioxidant agent, on the ischemia/reperfusion (I/R) injury in rat retina histopathologically. Methods: The retinal I/R model was carried out by the 4-vessel occlusion method on Wistar albino rats. Twenty-one rats were divided into 7 groups, each comprising 3 rats. The animals in groups 1, 2 and 3 underwent 30 min of ischemia + 4 h of reperfusion and were treated by the administration of saline, TMZ before reperfusion and TMZ before ischemia, respectively. The animals in groups 4, 5 and 6 underwent 90 min of ischemia + 4 h of reperfusion and were treated in the same way as those in groups 1, 2 and 3, respectively. The 7th group was sham operated. Results: Thirty and 90 min of ischemia followed by 4 h of reperfusion induced retinal injury in the rat retina. Histopathologically, the inner plexiform and inner nuclear layers were the most affected parts. TMZ was able to reduce almost all retinal I/R damage when administered before ischemia. A cytoprotective effect of TMZ was partly observed in those animals which were treated before reperfusion. Conclusion: TMZ seemed to have a protective effect against retinal I/R injury in rats. Copyright © 2001 S. Karger AG, Basel. | URI: | https://hdl.handle.net/11499/5469 https://doi.org/10.1159/000050880 |
ISSN: | 0030-3755 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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