Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5469
Title: Effect of trimetazidine on retinal ischemia/reperfusion injury in rats
Authors: Özden, Serap
Kıldacı, Bahriye
Muftuoglu, S.
Cakar, N.
Yıldırım, Cem
Keywords: Rat retina
Retinal ischemia/reperfusion
Trimetazidine
trimetazidine
animal experiment
article
cell protection
controlled study
histopathology
nonhuman
rat
reperfusion injury
retina bipolar ganglion cell
retina injury
retina ischemia
Animals
Antioxidants
Cytoprotection
Models, Animal
Rats
Rats, Wistar
Reperfusion Injury
Retina
Abstract: Purpose: To investigate the effect of trimetazidine (TMZ), an antioxidant agent, on the ischemia/reperfusion (I/R) injury in rat retina histopathologically. Methods: The retinal I/R model was carried out by the 4-vessel occlusion method on Wistar albino rats. Twenty-one rats were divided into 7 groups, each comprising 3 rats. The animals in groups 1, 2 and 3 underwent 30 min of ischemia + 4 h of reperfusion and were treated by the administration of saline, TMZ before reperfusion and TMZ before ischemia, respectively. The animals in groups 4, 5 and 6 underwent 90 min of ischemia + 4 h of reperfusion and were treated in the same way as those in groups 1, 2 and 3, respectively. The 7th group was sham operated. Results: Thirty and 90 min of ischemia followed by 4 h of reperfusion induced retinal injury in the rat retina. Histopathologically, the inner plexiform and inner nuclear layers were the most affected parts. TMZ was able to reduce almost all retinal I/R damage when administered before ischemia. A cytoprotective effect of TMZ was partly observed in those animals which were treated before reperfusion. Conclusion: TMZ seemed to have a protective effect against retinal I/R injury in rats. Copyright © 2001 S. Karger AG, Basel.
URI: https://hdl.handle.net/11499/5469
https://doi.org/10.1159/000050880
ISSN: 0030-3755
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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