Efficiency and reliability of serum hepcidin level measurement in evaluation of disease activation in patients with ulcerative colitis.

Abstract

Purpose: The study is to examine the relationship between hepcidin and inflammation markers and disease severity Materials and methods: Hepcidin levels are determined in 108 Ulcerative Colitis patients and 56 control subjects, a total of 164 subjects, equally active and in remission. Correlations between hepcidin levels and Age, Gender, ESR, CRP, WBC Hb levels are determined in the data. The relationship between hepcidin level of active UC patients and Age, Gender, ESR, CRP, WBC, Hb, Truelove-Witts score and Mayo score is evaluated by regression analysis. Results: ESR, CRP and Hepcidin levels in the Active Ulcerative Colitis group are statistically significantly higher than in the remission and control groups; ESR, CRP, Hepcidin levels are found to be statistically significantly higher in the entire ulcerative colitis group compared to the control group. In addition, a statistically significant positive correlation is found between the hepcidin level and the Truelove Witts score and the Mayo score in the AUC group (p<0.05).In the regression analysis perform to determine the factors affecting hepcidin level in ulcerative colitis patients, increase in Age (B=0.143, p<0.05), increase in Truelove Witts Score (B=5.224, p<0.001) increased Hepcidin level, whereas increase in Erythrocyte Sedimentation Rate decreased hepcidin level (B=-0.160, p<0.05) is determined. Conclusion: It is promising that serum hepcidin level can enter into clinical use as a marker that can be used to evaluate not only disease activation but also the severity of activation. © 2024, Pamukkale University. All rights reserved.