Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/54847
Title: Evaluation of the dynamic thiol/disulfide homeostasis in patients with chronic venous insufficiency
Authors: Müdüroğlu, Ayhan
Velioğlu, Yusuf
Çelik, Hümeyra
Yüksel, Ahmet
Aldemir, Mustafa
Atasoy, Mustafa Selçuk
Kılıç, Ali Önder
Çetintaş, Demir
Badem, Serdar
Çayır, Mustafa Çağdaş
Bal, Ceylan
Keywords: Biomarker
Chronic venous insufficiency
Dynamic thiol/disulfide homeostasis
Oxidative stress
Publisher: Elsevier Inc.
Abstract: Objective: There is no study in the literature evaluating the dynamic thiol/disulfide homeostasis in patients with chronic venous insufficiency. Thus, we designed this study to evaluate the dynamic thiol/disulfide homeostasis as a novel indicator of oxidative stress in patients with chronic venous insufficiency. Methods: This was a prospective case-control study performed at the department of cardiovascular surgery of a tertiary referral hospital in Turkey. A total of 80 (CEAP C3-C6) patients with lower extremity chronic venous insufficiency (as the study group) and 80 healthy subjects (as the control group) were enrolled to the study. The participants’ basic demographic and clinical characteristics as well as serum levels of some laboratory parameters including albumin, ferroxidase, myeloperoxidase, native thiol, total thiol, disulphide, native thiol/total thiol, disulphide/native thiol, and disulphide/total thiol were determined, and then compared between the groups. Results: In terms of basic demographic and clinical characteristics, both groups were statistically similar, and there were no significant differences between the groups. When the laboratory parameters were considered, serum ferroxidase and myeloperoxidase levels were detected to be significantly higher, whereas albumin, native thiol, total thiol, and disulphide levels were detected to be significantly lower in the study group than in the control group. Conclusions: Dynamic thiol/disulphide homeostasis could be considered as an indicator reflecting the oxidative stress status in patients with chronic venous insufficiency. © 2023 Society for Vascular Surgery
URI: https://doi.org/10.1016/j.jvsv.2023.09.003
https://hdl.handle.net/11499/54847
ISSN: 2213-333X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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