Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/54848
Title: Postmortem biochemistry in deaths from ischemic heart disease
Authors: Kutlu, E.
Avci, Esin
Acar, K.
Keywords: Biomarker
Ischemic heart disease
Myocardial infarction
Postmortem biochemistry
Sudden cardiac death
atrial natriuretic factor
biochemical marker
biological marker
brain natriuretic peptide
copeptin
creatine kinase
fatty acid binding protein 3
ischemia modified albumin
lactate dehydrogenase
myoglobin
myosin
pentraxin 3
pregnancy associated plasma protein A
troponin T
acute heart infarction
autopsy
biochemistry
body fluid
clinical classification
clinical practice
controlled study
death
electrocardiogram
electrocardiography
heart infarction
heart muscle ischemia
histopathology
human
ischemic heart disease
morbidity
postmortem computed tomography
postmortem interval
public health problem
resuscitation
Review
sudden cardiac death
Publisher: Churchill Livingstone
Abstract: Ischemic heart disease (IHD) is one of the leading causes of morbidity and sudden cardiac death worldwide and is an important public health problem. The presence of ischemia in clinical applications can be detected by ECG, biochemical markers, and radiological methods. Myocardial infarction is also frequently encountered in forensic autopsies. Postmortem diagnosis is determined as a result of histopathological examinations and additional exclusionary examinations (toxicology, microbiology, etc.). However, routine histopathological examinations are insufficient, especially when death occurs in the early period of ischemia. It creates a problem for forensic pathologists and forensic medicine specialists in such cases of sudden cardiac death. Postmortem biochemistry is one of the important and promising disciplines in which forensic applications work in order to diagnose these cases correctly. The issue of whether biomarkers used in the diagnosis of myocardial infarction in clinical studies can be used reliably in postmortem cases has been discussed by forensic medicine researchers for some time. This manuscript aims to review and summarize biomarkers belonging to various categories that have been studied in IHD-related deaths, in biological fluids taken at autopsy, or in animal experiments. Our study shows that the postmortem use of biochemical markers in the diagnosis of IHD yields promising results. However, it should not be forgotten that postmortem biochemistry is different from clinical applications due to its dynamics and that the body causes unpredictable changes in markers in the postmortem process. Therefore, comprehensive studies are needed to evaluate the postmortem stability of these markers in different biological fluids, their significance among various causes of death, and whether they are affected by any variable (Cardiopulmonary resuscitation, Postmortem interval, medications, etc.) before they are routinely applied. It is suggested by the authors that the cut-off values of biomarkers whose significance has been proven by these studies should be determined and that they should be used in this way in routine applications. © 2023 Elsevier Ltd and Faculty of Forensic and Legal Medicine
URI: https://doi.org/10.1016/j.jflm.2023.102599
https://hdl.handle.net/11499/54848
ISSN: 1752-928X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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