Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5504
Title: Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice
Authors: Kaar, S.G.
Ragab, A.A.
Kaye, S.J.
Kılıç, Bekir Alper
Jinno, T.
Goldberg, V.M.
Bi, Y.
Keywords: Implants (surgical)
Repair
Sorption
Titanium
Microradiographs
Osteolysis
Orthopedics
titanium
aged
aging
animal experiment
animal model
animal tissue
article
bone development
bone remodeling
controlled study
disease model
endoprosthesis loosening
female
histopathology
implant
male
microradiography
morphometrics
mouse
nonhuman
orthopedic surgery
ossification
osteolysis
particle size
priority journal
skeleton
skull
treatment planning
Publisher: Elsevier BV
Abstract: Aseptic loosening is the most common cause of orthopaedic implant failure. This process is thought to be due to osteolysis induced by implant-derived wear particles. Teitelbaum and colleagues have recently developed a promising murine calvarial model of wear particle-induced osteolysis. However, prior to this study, this model had only been assessed qualitatively. We now report a reproducible, quantitative version of the calvarial model of wear particle-induced osteolysis, in which the extent of osteolysis (and repair) of entire parietal bones is assessed by histomorphometry of contact microradiographs. Using this model, we found that the osteolytic response is transient and rapidly repaired in one month old mice. The extent of osteolysis peaks 7 days after particle implantation and returns to baseline levels by 13 days. A similar amount of osteolysis and even more extensive repair is observed when particles are implanted repeatedly. In contrast, aged mice develop progressive osteolysis with no detectable repair. As a result,. 26 month old mice have approximately 17-fold more osteolysis than one month old mice 21 days after particle implantation. Skeletally mature, adult mice (4-16 months old) show an intermediate pattern of response. Osteolysis in these mice peaks at 7 days after particle implantation but it is repaired more slowly than in the one month old mice. Taken together, these results underscore the role of an imbalance between bone resorption and bone formation in the development of aseptic loosening and suggest that agents that stimulate bone formation maybe useful in prevention or treatment of aseptic loosening. © 2001 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.
URI: https://hdl.handle.net/11499/5504
https://doi.org/10.1016/S0736-0266(00)00033-4
ISSN: 0736-0266
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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