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https://hdl.handle.net/11499/5520
Title: | Coronary artery disease and infection with chlamydia pneumonia | Authors: | Kaftan, Asuman H. Kaftan, Osman |
Keywords: | Blood lipids Chlamydia pneumonia Coronary artery disease Inflammatory markers antibody C reactive protein fibrinogen immunoglobulin G lipid article blood case control study chlamydiasis coronary artery disease female human immunology male microbiology middle aged pneumonia prospective study Antibodies C-Reactive Protein Case-Control Studies Chlamydia Infections Coronary Disease Female Fibrinogen Humans Immunoglobulin G Lipids Male Middle Aged Pneumonia Prospective Studies |
Abstract: | The association between chlamydia pneumonia and coronary artery disease is well documented, however less is known about the correlation between chlamydia pneumonia infection and blood inflammatory markers or lipid levels. In 100 patients with proven coronary artery disease (25 females, 61.0 + 4.0 years old), and 60 healthy volunteer control cases (15 females, 60.6 ±3.4 years old), anti chlamydia pneumonia IgG, blood lipid, C-reactive protein and fibrinogen levels were detected. In cases with coronary artery disease seropositivity for IgG antibodies to chlamydia pneumonia (74% versus 34%, p < 0.0001 ), C-reactive protein (mg / /) (2.8 ±0.6 versus 1.4 ±0.6, p < 0.0001 ), fibrinogen (mg / d/) (317.4 ±38.2 versus 256.2 ±34.5, p < 0.0001 ), triglycéride (mg/dl) (217.5 ±39.0 versus 191.0 + 25.9, p <0.0001), LDL-cholesterol (mg /dl) (126.9+ 19.2 versus 110.6± 19.5, p< 0.0001) levels and total cholesterol / HDL-cholesterol ratio (7.7 ±1.8 versus 4.4 + 1.2, p < 0.0001) were higher but the level of HDL-cholesterol (mg/dl) (26.4±6.7 versus 47.0 ±11.2, p< 0.0001) was lower. The levels of total cholesterol did not differ between the two groups (/? = 0.9). Levels of triglycéride (r = 0.60, p< 0.00001), LDL-cholesterol (r = 0.27, p = 0.0004), C-reactive protein (r = 0.69, p < 0.00001), fibrinogen (r = 0.60, p<0.00001) and total cholesterol /HDLcholesterol ratio (r = 0.74, p< 0.00001) had a direct relation, but the level of HDL-cholesterol had a negative (r = -0.80, p< 0.00001) relation with the seropositivity for chlamydia pneumonia. As a result, seropositivity for IgG antibodies to chlamydia pneumonia is considered as a risk factor for coronary artery disease by its association with the atherogenic lipid profile and procoagulant activity. | URI: | https://hdl.handle.net/11499/5520 | ISSN: | 0021-4868 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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