Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5524
Title: Role of nitric oxide in hypoxia-induced changes in newborn rats
Authors: Kılıç, İlknur
Kılıç, Bekir Alper
Güven, C.
Demirpençe, Ediz
Akşit, Mehmet Akif
Keywords: Hypoxia
L-Arginine
N(G)-nitro-L-arginine
Newborn rats
Nitric Oxide
arginine
arginine derivative
myeloperoxidase
n(g) nitroarginine
nitric oxide
nitric oxide synthase inhibitor
animal experiment
animal model
animal tissue
article
brain
controlled study
enzyme activity
heart
histopathology
hypoxemia
intestine
intestine villus
kidney
lipid peroxidation
liver
lung
lung hemorrhage
newborn
nonhuman
pathogenesis
priority journal
rat
reperfusion injury
skeletal muscle
Animals
Animals, Newborn
Anoxia
Arginine
Enzyme Inhibitors
Intestines
Lipid Peroxides
Liver
Lung
Muscle, Skeletal
Nitroarginine
Peroxidase
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances
Abstract: In order to investigate the role of nitric oxide (NO) in hypoxic tissue damage in newborns, we studied the effects of systemic administration of an inhibitor of NO synthase, N(G)-nitro-L-arginine (L-NNA), and the precursor for the synthesis of NO,L-arginine (L-ARG), on the biochemical and histological changes in brain, heart, lung, liver, kidney, intestine, and skeletal muscle tissues. Four groups of 1-day-old Wistar rat pups were used: control, hypoxic, L-ARG, and L-NNA groups. L-ARG 100 mg/kg or L-NNA 2 mg/kg was administered as a bolus intraperitoneally 1.5 h before hypoxia. Hypoxia increased lipid peroxidation in all tissues except muscle; this increase was prevented by L-NNA and L-ARG in brain, heart, lung, kidney, and liver tissues. L-NNA in intestine and L-ARG in muscle tissue increased lipid peroxidation. The tissue-associated myeloperoxidase activity was decreased in the liver by L-NNA and L-ARG. Histopathological changes in intestines were villous epithelial separation and hyperemia in hypoxic and L-NNA groups which were not observed in control and L-ARG groups. In lungs, pulmonary hemorrhage was observed only in the hypoxic group. These data suggest that NO acts both as a destructive and a protective agent in the pathogenesis of hypoxia-reoxygenation injuries. Copyright (C) 2000 S. Karger AG, Basel.
URI: https://hdl.handle.net/11499/5524
https://doi.org/10.1159/000014270
ISSN: 0006-3126
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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