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https://hdl.handle.net/11499/5524
Title: | Role of nitric oxide in hypoxia-induced changes in newborn rats | Authors: | Kılıç, İlknur Kılıç, Bekir Alper Güven, C. Demirpençe, Ediz Akşit, Mehmet Akif |
Keywords: | Hypoxia L-Arginine N(G)-nitro-L-arginine Newborn rats Nitric Oxide arginine arginine derivative myeloperoxidase n(g) nitroarginine nitric oxide nitric oxide synthase inhibitor animal experiment animal model animal tissue article brain controlled study enzyme activity heart histopathology hypoxemia intestine intestine villus kidney lipid peroxidation liver lung lung hemorrhage newborn nonhuman pathogenesis priority journal rat reperfusion injury skeletal muscle Animals Animals, Newborn Anoxia Arginine Enzyme Inhibitors Intestines Lipid Peroxides Liver Lung Muscle, Skeletal Nitroarginine Peroxidase Rats Rats, Wistar Thiobarbituric Acid Reactive Substances |
Abstract: | In order to investigate the role of nitric oxide (NO) in hypoxic tissue damage in newborns, we studied the effects of systemic administration of an inhibitor of NO synthase, N(G)-nitro-L-arginine (L-NNA), and the precursor for the synthesis of NO,L-arginine (L-ARG), on the biochemical and histological changes in brain, heart, lung, liver, kidney, intestine, and skeletal muscle tissues. Four groups of 1-day-old Wistar rat pups were used: control, hypoxic, L-ARG, and L-NNA groups. L-ARG 100 mg/kg or L-NNA 2 mg/kg was administered as a bolus intraperitoneally 1.5 h before hypoxia. Hypoxia increased lipid peroxidation in all tissues except muscle; this increase was prevented by L-NNA and L-ARG in brain, heart, lung, kidney, and liver tissues. L-NNA in intestine and L-ARG in muscle tissue increased lipid peroxidation. The tissue-associated myeloperoxidase activity was decreased in the liver by L-NNA and L-ARG. Histopathological changes in intestines were villous epithelial separation and hyperemia in hypoxic and L-NNA groups which were not observed in control and L-ARG groups. In lungs, pulmonary hemorrhage was observed only in the hypoxic group. These data suggest that NO acts both as a destructive and a protective agent in the pathogenesis of hypoxia-reoxygenation injuries. Copyright (C) 2000 S. Karger AG, Basel. | URI: | https://hdl.handle.net/11499/5524 https://doi.org/10.1159/000014270 |
ISSN: | 0006-3126 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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