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Title: | Value of p53 protein in biological behavior of basal cell carcinoma and in normal epithelia adjacent to carcinomas | Authors: | Calli Demirkan, Neşe Colakoglu, N. Düzcan, E. |
Keywords: | Ageing Basal cell carcinoma P53 protein monoclonal antibody monoclonal antibody DO7 protein p53 unclassified drug adult age aged article basal cell carcinoma clinical article epithelium cell gene mutation human human cell immunoreactivity protein expression tumor cell tumor differentiation tumor growth tumor recurrence tumor suppressor gene Age Factors Aged Carcinoma, Basal Cell Disease Progression Epithelium Humans Keratinocytes Middle Aged Skin Neoplasms Tumor Suppressor Protein p53 |
Abstract: | Mutations in p53 gene are the most frequent gene alterations in human cancer. In this study, we have used the monoclonal antibody (DO7) to evaluate the role of the p53 gene mutation in the progression of basal cell carcinomas towards invasion. We tested the positivity for p53 protein in tumor cells in six cases of basosquamous cell carcinoma (BSCC), in twelve cases of infiltrative basal cell carcinoma (IBCC) and twenty-four cases of non-infiltrative basal cell carcinoma (NIBCC) in order to evaluate its potential prognostic significance. We also tested the expression of p53 protein in normal epithelia adjacent to carcinomas in order to determine its role in tumor progression. p53 protein staining with some peripheral accentuation was identified in 42,9% of all groups. No correlation was found between the immunreactivity of p53 protein and recurrence, pattern of tumor, diameter of the tumors and sex. However, there were statistically significant differences in positivity of p53 protein in normal epithelia adjacent to carcinomas and age of patients (t value: 2,21; p: 0,034). Results of the study suggest that the increase in p53 mutation frequency of morphologically normal epidermis was related to age and was independent of the degree of differentiation of BCC. © 2000 W B. Saunders and Company Ltd on behalf of the Ar£nyi Lajos Foundation. | URI: | https://hdl.handle.net/11499/5551 | ISSN: | 1219-4956 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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