Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5551
Title: Value of p53 protein in biological behavior of basal cell carcinoma and in normal epithelia adjacent to carcinomas
Authors: Calli Demirkan, Neşe
Colakoglu, N.
Düzcan, E.
Keywords: Ageing
Basal cell carcinoma
P53 protein
monoclonal antibody
monoclonal antibody DO7
protein p53
unclassified drug
adult
age
aged
article
basal cell carcinoma
clinical article
epithelium cell
gene mutation
human
human cell
immunoreactivity
protein expression
tumor cell
tumor differentiation
tumor growth
tumor recurrence
tumor suppressor gene
Age Factors
Aged
Carcinoma, Basal Cell
Disease Progression
Epithelium
Humans
Keratinocytes
Middle Aged
Skin Neoplasms
Tumor Suppressor Protein p53
Abstract: Mutations in p53 gene are the most frequent gene alterations in human cancer. In this study, we have used the monoclonal antibody (DO7) to evaluate the role of the p53 gene mutation in the progression of basal cell carcinomas towards invasion. We tested the positivity for p53 protein in tumor cells in six cases of basosquamous cell carcinoma (BSCC), in twelve cases of infiltrative basal cell carcinoma (IBCC) and twenty-four cases of non-infiltrative basal cell carcinoma (NIBCC) in order to evaluate its potential prognostic significance. We also tested the expression of p53 protein in normal epithelia adjacent to carcinomas in order to determine its role in tumor progression. p53 protein staining with some peripheral accentuation was identified in 42,9% of all groups. No correlation was found between the immunreactivity of p53 protein and recurrence, pattern of tumor, diameter of the tumors and sex. However, there were statistically significant differences in positivity of p53 protein in normal epithelia adjacent to carcinomas and age of patients (t value: 2,21; p: 0,034). Results of the study suggest that the increase in p53 mutation frequency of morphologically normal epidermis was related to age and was independent of the degree of differentiation of BCC. © 2000 W B. Saunders and Company Ltd on behalf of the Ar£nyi Lajos Foundation.
URI: https://hdl.handle.net/11499/5551
ISSN: 1219-4956
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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