Reference intervals of serum folate and vitamin B12 developed from data of healthy subjects

Abstract

In this study the reference intervals for folate and vitamin B12 were estimated according to the National Committee for Clinical Laboratory Standards Approved Guideline C28-A and International Federation of Clinical Chemistry recommendations. The study included 155 women and 124 men between ages 18-40. The health status was confirmed by history, physical examination and a questionnaire. The central 95% reference intervals of serum folate and vitamin B12 for women, determined non-parametrically, were found to be 3.9-18.1 ng/ml and 101-666.7 pg/ml, respectively. The reference values of serum folate and vitamin B12 for men were also found to be 2,5-17.6 ng/ml and 100-699.57 pg/ml, respectively. We did not observe subclass differences between females and males.