Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5557
Title: A new therapeutic approach for the treatment of cystic echinococcosis: Percutaneous albendazole sulphoxide injection without reaspiration
Authors: Değer, Emin
Hokelek, M.
Deger, B.A.
Tutar, E.
Asil, M.
Pakdemirli, Emre
Keywords: albendazole sulfoxide
animal experiment
animal model
antibiotic therapy
article
controlled study
cost effectiveness analysis
drug efficacy
drug safety
echinococcosis
echography
injection
liver hydatid cyst
nonhuman
priority journal
sheep
treatment outcome
Albendazole
Animals
Anticestodal Agents
Cysts
Echinococcosis, Hepatic
Injections, Intralesional
Liver
Sheep
Suction
Abstract: OBJECTIVE: In this experimental study, the effectiveness of intracystic injection of albendazole sulfoxide solution was investigated as a new approach to percutaneous treatment in liver hydatid disease. METHODS: Ten naturally infected sheep were selected and divided into two groups: a treatment group (n = 7), and a control group (n = 3). Intracystic injection of albendazole sulfoxide was performed in the first group, whereas the control group received intracystic distillated water injection instead. No reaspiration was performed in any group. RESULTS: During the follow-up period of 6 months, serial sonographic examination revealed a significant decrease in the cyst size, progressive solidification, and complete separation of the germinal and the laminated membranes of hydatid cysts from the pericysts in the treatment group. In the control group, diameters and volumes of cysts were increased. All procedures were done without any complications. During the follow-up-period, liver function tests were normal. After 6 months, all sheep were killed and were examined for macroscopic and microscopic changes. Pathological examination showed pericyst hyalinization, inflammatory cells in the cyst wall, degeneration of laminated and germinal membranes, and necrotic material in the cyst cavity. No viable protoscoleces or daughter cysts were observed. CONCLUSION: Albendazole sulfoxide injection as a scolecidal agent in the percutaneous treatment of cystic echinococcosis seems to be effective in this animal model. Further studies are suggested to evaluate the effectiveness of this procedure in human subjects.
URI: https://hdl.handle.net/11499/5557
https://doi.org/10.1016/S0002-9270(99)00711-X
ISSN: 0002-9270
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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