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https://hdl.handle.net/11499/5557
Title: | A new therapeutic approach for the treatment of cystic echinococcosis: Percutaneous albendazole sulphoxide injection without reaspiration | Authors: | Değer, Emin Hokelek, M. Deger, B.A. Tutar, E. Asil, M. Pakdemirli, Emre |
Keywords: | albendazole sulfoxide animal experiment animal model antibiotic therapy article controlled study cost effectiveness analysis drug efficacy drug safety echinococcosis echography injection liver hydatid cyst nonhuman priority journal sheep treatment outcome Albendazole Animals Anticestodal Agents Cysts Echinococcosis, Hepatic Injections, Intralesional Liver Sheep Suction |
Abstract: | OBJECTIVE: In this experimental study, the effectiveness of intracystic injection of albendazole sulfoxide solution was investigated as a new approach to percutaneous treatment in liver hydatid disease. METHODS: Ten naturally infected sheep were selected and divided into two groups: a treatment group (n = 7), and a control group (n = 3). Intracystic injection of albendazole sulfoxide was performed in the first group, whereas the control group received intracystic distillated water injection instead. No reaspiration was performed in any group. RESULTS: During the follow-up period of 6 months, serial sonographic examination revealed a significant decrease in the cyst size, progressive solidification, and complete separation of the germinal and the laminated membranes of hydatid cysts from the pericysts in the treatment group. In the control group, diameters and volumes of cysts were increased. All procedures were done without any complications. During the follow-up-period, liver function tests were normal. After 6 months, all sheep were killed and were examined for macroscopic and microscopic changes. Pathological examination showed pericyst hyalinization, inflammatory cells in the cyst wall, degeneration of laminated and germinal membranes, and necrotic material in the cyst cavity. No viable protoscoleces or daughter cysts were observed. CONCLUSION: Albendazole sulfoxide injection as a scolecidal agent in the percutaneous treatment of cystic echinococcosis seems to be effective in this animal model. Further studies are suggested to evaluate the effectiveness of this procedure in human subjects. | URI: | https://hdl.handle.net/11499/5557 https://doi.org/10.1016/S0002-9270(99)00711-X |
ISSN: | 0002-9270 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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