Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/5564
Title: | Premarital screening of beta-thalassemia trait in the province of Denizli, Turkey | Authors: | Keskin, Ali Türk, Tufan Polat, Aziz Koyuncu, Hasan Saracoglu, Berna |
Keywords: | Premarital screening Turkey ß-Thalassemia trait hemoglobin A2 article beta thalassemia diagnostic value disease carrier disease control female genetic counseling genetic screening hemoglobin determination human major clinical study male marriage pregnancy termination prenatal diagnosis prevalence priority journal sickle cell trait Turkey (republic) |
Publisher: | S. Karger AG | Abstract: | A premarital screening program aiming at reducing the incidence of thalassemia major was started under the auspices of the Regional Health Administration in 1995 in the city of Denizli in the Aegean region of Turkey. In this report we assessed the 4-year results of the screening program. All couples who applied for marriage procedures were screened for ß-thalassemia trait by automatic red cell indices and Hb A2 determination. The couples at risk were counseled and offered prenatal diagnosis and termination of pregnancy in case of an affected fetus. From October 1995 to August 1999, a total of 19,804 subjects (9,902 couples) were recruited for this study. The prevalence of ß-thalassemia trait with increased Hb A2 was found to be 2.6% (514/19,804). In addition to the thalassemia trait, 22 patients (0.11%) had sickle trait. In 15 of the 9,902 couples, both partners were found to be carriers of the ß-thalassemia trait. After genetic counseling, 2 of the 15 planned carrier marriages were canceled. Seven couples declared that they do not want to have a child at present. Prenatal diagnosis was sought by 6 couples. One fetus was found to be normal, 4 had thalassemia minor and 1 had thalassemia major; this pregnancy was terminated by elective abortion. This study indicated that premarital screening is a very useful tool for detecting carrier couples and an effective way of controlling thalassemia major. Copyright (C) 2000 S. Karger AG, Basel. | URI: | https://hdl.handle.net/11499/5564 https://doi.org/10.1159/000041066 |
ISSN: | 0001-5792 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
59
checked on Sep 30, 2024
WEB OF SCIENCETM
Citations
48
checked on Oct 8, 2024
Page view(s)
44
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.