Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5571
Title: Cerebral protection with trimetazidine in transient brain ischemia in rats
Authors: Baltalarlı, Ahmet.
Coşkun, Erdal.
Us, M.H.
Rendeci, Oya.
Ortaç, R.
Şirin, Bekir Hayrettin.
Keywords: sodium chloride
trimetazidine
animal experiment
animal model
animal tissue
article
brain protection
carotid artery obstruction
controlled study
drug efficacy
evoked somatosensory response
hippocampus
histopathology
male
nonhuman
priority journal
rat
reperfusion injury
scoring system
symptom
transient ischemic attack
treatment outcome
Publisher: Springer New York
Abstract: The neuroprotective effect of trimetazidine (TMZ) on ischemic- reperfusion injury was tested by randomized, controlled, prospective study in a rat model of transient global cerebral ischemia. Thirty wistar albino rats were used for study. Animals in TMZ group (n = 10) received trimetazidine (3 mg/kg IV bolus) before the occlusion of carotid arteries. A similar volume of saline solution was used in the control group (n = 10). The sham group (n = 10) were anaesthetized and subjected to operative dissections without vascular occlusion. Physiological parameters, somatosensory evoked potentials (SEP's) were monitored. The neurological outcomes had been clinically evaluated and scored up to 4 days post ischemia. the intergroup differences were compared. Histological observations were clearly correlated with the neurological findings. the percentage of damaged neurons in CA1 and CA3 in subfield of hypochampus 34 ± 6% and 16 ± 6% in the TMZ group, whereas it was 44 ± 5% and 24 ± 5% in the control group (p < 0.05). The average neurologic score was significantly better in animals which received TMZ than in the controls at postoperative 24 hours (17.9 ± 1.4 in the TMZ group and 14.9 ± 1.6 in the control group, p < 0.05). The results suggest that trimetazidine reduces cerebral injury and preserves neurological function in transient global ischemia in rats.
URI: https://hdl.handle.net/11499/5571
https://doi.org/10.1007/BF01616503
ISSN: 1061-1711
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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