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https://hdl.handle.net/11499/5571
Title: | Cerebral protection with trimetazidine in transient brain ischemia in rats | Authors: | Baltalarlı, Ahmet. Coşkun, Erdal. Us, M.H. Rendeci, Oya. Ortaç, R. Şirin, Bekir Hayrettin. |
Keywords: | sodium chloride trimetazidine animal experiment animal model animal tissue article brain protection carotid artery obstruction controlled study drug efficacy evoked somatosensory response hippocampus histopathology male nonhuman priority journal rat reperfusion injury scoring system symptom transient ischemic attack treatment outcome |
Publisher: | Springer New York | Abstract: | The neuroprotective effect of trimetazidine (TMZ) on ischemic- reperfusion injury was tested by randomized, controlled, prospective study in a rat model of transient global cerebral ischemia. Thirty wistar albino rats were used for study. Animals in TMZ group (n = 10) received trimetazidine (3 mg/kg IV bolus) before the occlusion of carotid arteries. A similar volume of saline solution was used in the control group (n = 10). The sham group (n = 10) were anaesthetized and subjected to operative dissections without vascular occlusion. Physiological parameters, somatosensory evoked potentials (SEP's) were monitored. The neurological outcomes had been clinically evaluated and scored up to 4 days post ischemia. the intergroup differences were compared. Histological observations were clearly correlated with the neurological findings. the percentage of damaged neurons in CA1 and CA3 in subfield of hypochampus 34 ± 6% and 16 ± 6% in the TMZ group, whereas it was 44 ± 5% and 24 ± 5% in the control group (p < 0.05). The average neurologic score was significantly better in animals which received TMZ than in the controls at postoperative 24 hours (17.9 ± 1.4 in the TMZ group and 14.9 ± 1.6 in the control group, p < 0.05). The results suggest that trimetazidine reduces cerebral injury and preserves neurological function in transient global ischemia in rats. | URI: | https://hdl.handle.net/11499/5571 https://doi.org/10.1007/BF01616503 |
ISSN: | 1061-1711 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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