Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5574
Title: Effects of epidural metoprolol and verapamil on the quality of blockade induced by lidocaine
Authors: Tomatir, E.
Serin, S.
Atalay, H.
Gurses, E.
Tomatir, A.G.
Gonullu, M.
Keywords: Beta blocker
Calcium channel blocker
Drug interaction
Epidural anaesthesia
Lidocaine
Local anaesthetic
Metoprolol
Verapamil
aritmal
beta adrenergic receptor blocking agent
calcium channel blocking agent
lidocaine
local anesthetic agent
metoprolol tartrate
unclassified drug
verapamil
animal experiment
antinociception
article
controlled study
dose response
drug potency
drug potentiation
epidural anesthesia
male
motor performance
nerve block
nonhuman
pain threshold
rat
tail flick test
Abstract: Inadequaecy of block quality in epidural anaesthesia is a challenging problem in clinical practice. It has been shown that intrathecal calcium channel blocker, verapamil, potentiates spinal anaesthesia with local anaesthetics. However, it has not been investigated the effects of epidural verapamil. It is also unknown whether epidural beta adrenergic receptor blockers which have local anaesthetic-like action, affect quality of block with local anaesthetics. In this study, we aimed to determine the effects of epidural verapamil or beta blocker, metoprolol, on the quality of block induced by lidocaine. Fourty male Wistar rats were chronically implanted with lomber epidural catheter. Tail flick (TF) and mechanical paw pressure (MPP) tests were used to assess thermal and mechanical antinociceptive thresholds, respectively. Motor function was assessed using a modified Langerman's scale. Although epidural verapamil (75 ?g) or metoprolol (30 ?g) alone showed neither sensory and motor block, the combination of lidocaine (100, 200, 400 ve 800 ?g) and verapamil or metoprolol produced more potent sensory and motor block when compared with lidocaine alone. We concluded that epidural metoprolol and verapamil increase quality of block induced by lidocaine, and further experimental studies are needed to be used in human.
URI: https://hdl.handle.net/11499/5574
ISSN: 1016-5150
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

Show full item record



CORE Recommender

Page view(s)

122
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.