The effectiveness of subhypnotic propofol for preventing undesired effects of morphine in unilateral anaestheia

Abstract

This clinical study has proposed to investigate the effect of subhypnotic doses of propofol which is used to prevent side effects of morphine commonly utilized for anaesthesia and postoperative analgesia. This study is planned in total forty ASA I-II class patients whom had unilateral inguinal hernia and artroscopy. Long chain trigliserid solution (LCT) 1 mL in group I (n=20) and propofol 1 mL in group II (n=20) applied intravenously before unilateral spinal anaesthesia. Bupivacaine 7.5 mg and morphine 0.1 mg used for unilateral spinal anaesthesia. Either 3 mL propofol or LCT in 1000 mL ringer lactate solution infused for preventing side effects during postoperative 24 hours. Pain, nausea, vomiting, pruritis, sedation score, urinary retention were evaluated pre and postoperatively. None of the parameters except pruritis were statistically significant between groups. The incidence of pruritus was statistically significant in group I during preoperative and postoperative period. It was concluded that subhypnotic dose of propofol can be used to reduce pruritus resulting from intrathecal 0.1 mg morphine which is commonly used for unilateral anaesthesia and postoperative analgesia.